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AbcamBiochemicals (Asc-013)

(±)-Anatoxin A fumarate (ab120013)

Q&A (7)

Overview

  • Product name(±)-Anatoxin A fumarate
  • Description
    Potent nicotinic agonist
  • Biological descriptionPotent nicotinic agonist. Neurotoxic alkaloid produced by the cyanobacterium Anabaena flos-aquae. KI values are 1.25 and 1840 nM for α4β2 and α7 nicotinic receptors in rat brain respectively.
  • Purity> 98%

    • Properties

  • Chemical name(±)-2-Acetyl-9-azabicyclo[4.2.1]non-2-ene fumarate
  • Molecular Weight281.31
  • Chemical structureChemical Structure
  • Molecular formulaC10H15NO.C4H4O4
  • CAS Number64285-06-9
  • PubChem identifier45073416
  • Storage instructionsStore at +4°C (desiccating conditions).
  • Solubility overviewSoluble in water to 50 mM
  • Handling

    Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

  • SMILESO=C(O)/C=C/C(=O)O.CC(=O)C2=CCCC1CCC2N1
  • Source

    Synthetic

  • Research Areas

    • References for (±)-Anatoxin A fumarate (ab120013)

    This product has been referenced in:
    • Sharples CG  et al. UB-165: a novel nicotinic agonist with subtype selectivity implicates the alpha4beta2* subtype in the modulation of dopamine release from rat striatal synaptosomes. J Neurosci 20:2783-91 (2000). Read more (PubMed: 10751429) »
    • Stolerman IP  et al. Behavioural effects of anatoxin, a potent nicotinic agonist, in rats. Neuropharmacology 31:311-4 (1992). Read more (PubMed: 1630597) »
    • Zhang X  et al. Anatoxin-a a potent ligand for nicotinic cholinergic receptors in rat brain. Eur J Pharmacol 135:457-8 (1987). Read more (PubMed: 3582504) »

    See 0 Publications for this product

    Publishing research using ab120013 ? Please let us know so that we can cite the reference in this datasheet

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    Submit a Question for ab120013

    Displaying 1 - 7 of 7 results for Q&A

    10
    Votes: Highest First

    We source Anatoxin-a from your company. Can you please confirm the correct MW of this item. The source lot number is APN10029-3-2. Is this the fumarate salt form of the item?

    The molecular weight of ab120013 anatoxin A fumarate is 281.31 and its in the fumarate salt form.

    J'ai passé en HPLC le standard anatoxin-A fumarate (100mg/L) et sur mon chromatogramme j'obtiens deux pics.
    Je me demande donc si le produit est bien pur.
    Je vous joins mon chromatogramme.
    J'ai bien reçu votre mail avec le chr...

    Read More



    La présence de 2 pics a également été observée en HPLC lors de la détermination de la pureté du produit. Le lot de ab120013 que vous avez reçu a passé les controles qualité ca...

    Read More

    HPLC chromatogram + wavelength for maximum absorbance

    Veuillez trouver ci-joint le chromatogramme HPLC du produit ab120013 (asc-013).


    Lecomposé a été solubilisé dans l'eau, la longueur d'onde est de 230nm.

    J'espère que ces informations vous seront...

    Read More

    phone call - Can this product also be solublized in Acetonitrile? Indeed, the customer plans to use the product rather in GC not HPLC. Can you please also provide more recommendations in regards to the storage of this product (either in water or in aceton...

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    Mon collègue du laboratoire suggère de chauffer légèrement la solution (à 0.5mg/ml)et delapasser au bain à ultrason.

    phone call - product does not resolubilize completely in acetonitrile

    Merci pour votre appel et votre patience.

    Comme je viens de vous confirmer au téléphone, le laboratoire me confirm d'essayer de passer ce produit au bains aux ultrasons. Il est mieux de ne pas chauffer le produit, car, comme vous avez dit, le c...

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    phone call about storage and resolubilization

    Thank you for contacting us.

    I have contacted the laboratory in regards to this compound and am happy to confirm the following:

    Wecan confirm that this compound can be solubilised in Acetonitrile to 1mg per ml. As abcam biochemicals a...

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    Dear Sirs,

    in August 2011 we received Asc-013 – (+/-)-Anatoxin A fumarate, batch number APN10029-3-2. Our customer complained that they found two peaks with the same masses when they analyzed it with LC-MS-MS.


    Please send...

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    Thank you for your enquiry.

    I am sorry to hear you have some concerns regarding the quality of the ab120013 (±)-Anatoxin A fumarate you received.

    As requested, I have attached the data. It may be of interest to note that the smaller ...

    Read More

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"