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AbcamBiochemicals (Asc-110)

(-)-Bicuculline methochloride (ab120110)

Q&A (1)Specific References (3)

Overview

  • Product name(-)-Bicuculline methochloride
  • Description
    GABAA antagonist
  • Biological descriptionWater-soluble GABAA antagonist. Methochloride salt of (+)-bicuculline (ab120107). Actions on neuronal Ca2+-activated K+ channels reported.
  • Purity> 98%

    • Properties

  • Chemical name[S-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium chloride
  • Molecular Weight417.84
  • Chemical structureChemical Structure
  • Molecular formulaC21H20ClNO6
  • CAS Number53552-05-9
  • PubChem identifier56972147
  • Storage instructionsStore at +4°C (desiccating conditions).
  • Solubility overviewSoluble in water to 100 mM
  • Handling

    Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

  • SMILES[Cl-].C[N+]5(C)CCc1cc6OCOc6cc1[C@@H]5[C@H]4OC(=O)c3c4ccc2OCOc23
  • Source

    Synthetic

  • Research Areas

    • References for (-)-Bicuculline methochloride (ab120110)

    This product has been referenced in:
    • Seutin V & Johnson SW Recent advances in the pharmacology of quaternary salts of bicuculline. Trends Pharmacol Sci 20:268-70 (1999). Read more (PubMed: 10390643) »
    • Olsen RW  et al. Studies on the neuropharmacological activity of bicuculline and related compounds. Brain Res 102:283-99 (1976). Read more (PubMed: 1247886) »

    See all 3 Publications for this product

    Publishing research using ab120110 ? Please let us know so that we can cite the reference in this datasheet

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    Submit a Question for ab120110

    Displaying 1 - 1 of 1 results for Q&A

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    Votes: Highest First

    I would like to know the PKa value of Bicuculline methochloride!

    Thank you for contacting Abcam.

    Unfortunately we don’t have a pKa value listed for this compound. I have done a quick literature search and nothing seems to be coming up.

    Usually if we have any such figures (IC50, Kd, pKa) we would...

    Read More

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"