Overview

  • Product name(-)-Deguelin
  • Description
    Akt inhibitor. Anticancer agent.
  • Alternative names
    • (-)-cis-Deguelin
  • Biological descriptionAkt inhibitor. Anticancer agent. Inhibits cell growth (IC50 = 43.2 nM) in vitro. Anticancer and antiangiogenic activities in vivo.
  • Purity> 98%

Properties

  • Chemical name(7aS,13aS)-13,13a-Dihydro-9,10-dimethoxy-3,3-dimethyl-3H-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7(7aH)-one
  • Molecular weight394.42
  • Chemical structureChemical Structure
  • Molecular formulaC23H22O6
  • CAS Number522-17-8
  • Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overviewSoluble in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILESCOc1cc2c(OC[C@H]3Oc4c(ccc5OC(C)(C)C=Cc45)C(=O)[C@@H]23)cc1OC
  • Source

    Synthetic

  • Research areas

    References for (-)-Deguelin (ab120941)

    This product has been referenced in:
    • Kang HW  et al. Deguelin, an Akt inhibitor, down-regulates NF-?B signaling and induces apoptosis in colon cancer cells and inhibits tumor growth in mice. Dig Dis Sci 57:2873-82 (2012). Read more (PubMed: 22623043) »
    • Oh SH  et al. Identification of novel antiangiogenic anticancer activities of deguelin targeting hypoxia-inducible factor-1 alpha. Int J Cancer 122:5-14 (2008). Read more (PubMed: 17764071) »
    • Murillo G  et al. Deguelin inhibits the growth of colon cancer cells through the induction of apoptosis and cell cycle arrest. Eur J Cancer 38:2446-54 (2002). Read more (PubMed: 12460790) »

    See 0 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"