Biological descriptionAkt inhibitor. Anticancer agent. Inhibits cell growth (IC50 = 43.2 nM) in vitro. Anticancer and antiangiogenic activities in vivo.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 50 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Kang HW et al. Deguelin, an Akt inhibitor, down-regulates NF-?B signaling and induces apoptosis in colon cancer cells and inhibits tumor growth in mice. Dig Dis Sci57:2873-82 (2012).
Read more (PubMed: 22623043) »
Oh SH et al. Identification of novel antiangiogenic anticancer activities of deguelin targeting hypoxia-inducible factor-1 alpha. Int J Cancer122:5-14 (2008).
Read more (PubMed: 17764071) »
Murillo G et al. Deguelin inhibits the growth of colon cancer cells through the induction of apoptosis and cell cycle arrest. Eur J Cancer38:2446-54 (2002).
Read more (PubMed: 12460790) »