Overview

  • Product name
    (-)-Nutlin-3
  • Description
    Potent p53-MDM2 binding inhibitor
  • Alternative names
    • Nutlin 3a
  • Biological description

    Potent p53-MDM2 binding inhibitor (IC50 = 90 nM). Enantiomer of (+)-Nutlin-3 (ab144426). Shows antiproliferative effects (IC50 values are 2.2 and 1.3 µM for human skin and murine fibroblasts respectively). Shows antitumor effects in vivo. Orally active.

  • Purity
    > 98%

Properties

  • Chemical name
    4-[(4S,5R)-4,5-Bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one
  • Molecular weight
    581.50
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C30H30Cl2N4O4
  • CAS Number
    675576-98-4
  • PubChem identifier
    11433190
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CC(C)OC1=C(C=CC(=C1)OC)C2=N[C@H]([C@H](N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Haaland I  et al. Molecular mechanisms of nutlin-3 involve acetylation of p53, histones and heat shock proteins in acute myeloid leukemia. Mol Cancer 13:116 (2014). Read more (PubMed: 24885082) »
  • Yamauchi-Yamada A  et al. Immune escape phenomenon in molluscum contagiosum and the induction of apoptosis. J Dermatol 41:1058-64 (2014). Read more (PubMed: 25438641) »
  • Athanasakis E  et al. The p53 transcriptional pathway is preserved in ATMmutated and NOTCH1mutated chronic lymphocytic leukemias. Oncotarget 5:12635-45 (2014). Read more (PubMed: 25587027) »

See 0 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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