Activator of Ca2+-activated K+ channels and CFTR channels
Biological descriptionActivator of small and intermediate conductance Ca2+ activated K+ channels (SK). Also activates apical membrane Cl- conductance CFTR channel.
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
MacVinish LJ et al. EBIO, an agent causing maintained epithelial chloride secretion by co-ordinate actions at both apical and basolateral membranes. Pflugers Arch443 Suppl 1:S127-31 (2001).
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Syme CA et al. Pharmacological activation of cloned intermediate- and small-conductance Ca(2+)-activated K(+) channels. Am J Physiol Cell Physiol278:C570-81 (2000).
Read more (PubMed: 10712246) »
Jensen BS et al. Characterization of the cloned human intermediate-conductance Ca2+-activated K+ channel. Am J Physiol275:C848-56 (1998).
Read more (PubMed: 9730970) »