Overview

  • Product nameAnti-14-3-3 Tau antibody [AT1A1]See all 14-3-3 Tau primary antibodies ...
  • Description
    Mouse monoclonal [AT1A1] to 14-3-3 Tau
  • Tested applicationsWB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length Human 14-3-3 Tau purified from E. coli (NP_006817; amino acids 1-245).

  • Positive control
    • Human Brain Cortex and Pancreas tissue; Jurkat and Ramos cell lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab105326 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/2000. Predicted molecular weight: 28 kDa.
ELISA Use at an assay dependent dilution.
IHC-P Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionAdapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
  • Tissue specificityAbundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement.
  • Sequence similaritiesBelongs to the 14-3-3 family.
  • Post-translational
    modifications
    Ser-232 is probably phosphorylated by CK1.
  • Cellular localizationCytoplasm. In neurons, axonally transported to the nerve terminals.
  • Information by UniProt
  • Database links
  • Alternative names
    • 14 3 3 protein T cell antibody
    • 14 3 3 protein tau antibody
    • 14 3 3 protein theta antibody
    • 14 3 3 tau antibody
    • 14 3 3 theta antibody
    • 14-3-3 protein T-cell antibody
    • 14-3-3 protein tau antibody
    • 14-3-3 protein theta antibody
    • 1433T_HUMAN antibody
    • 1C5 antibody
    • HS1 antibody
    • KCIP1 antibody
    • Protein HS1 antibody
    • Protein kinase C inhibitor protein 1 antibody
    • Protein tau antibody
    • tyr3/trp5 monooxygenase activation protein, theta antibody
    • Tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein, theta polypeptide antibody
    • Ywhaq antibody
    see all

Anti-14-3-3 Tau antibody [AT1A1] images

  • ab105326, at 10 µg/ml, staining 14-3-3 Tau in formalin-fixed, paraffin-embedded Human Brain, Cortex by Immunohistochemistry, using a biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
  • ab105326, at 10 µg/ml, staining 14-3-3 Tau in formalin-fixed, paraffin-embedded Human Pancreas tissue by Immunohistochemistry, using a biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
  • Anti-14-3-3 Tau antibody [AT1A1] (ab105326) at 1/1000 dilution + Jurkat cell lysate

    Predicted band size : 28 kDa

References for Anti-14-3-3 Tau antibody [AT1A1] (ab105326)

ab105326 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"