Anti-14-3-3 Tau antibody [AT1A1] (ab105326)

Overview

• Product nameAnti-14-3-3 Tau antibody [AT1A1]See all 14-3-3 Tau primary antibodies ...
• Description
  Mouse monoclonal [AT1A1] to 14-3-3 Tau
• Tested applicationsWB, ELISA, IHC-P more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Recombinant full length Human 14-3-3 Tau purified from E. coli (NP_006817; amino acids 1-245).

• Positive controlHuman Brain Cortex and Pancreas tissue; Jurkat and Ramos cell lysates

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferPreservative: 0.1% Sodium Azide
  Constituents: PBS, pH 7.4
• Concentration information loading...
• PurityProtein G purified
• Clonality Monoclonal
• Clone numberAT1A1
• IsotypeIgG1
• Research Areas
  • Stem Cells
  • Signaling Pathways
  • Wnt
  • 14-3-3

  • Signal Transduction
  • Adapters
  • Cytoplasmic

  • Neuroscience
  • Neurology process
  • Neural Signal Transduction

  • Neuroscience
  • Cell Type Marker
  • Neuron marker
  • Synapse marker

Applications

Target

• FunctionAdapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
• Tissue specificityAbundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement.
• Sequence similaritiesBelongs to the 14-3-3 family.
• Post-translational
  modificationsSer-232 is probably phosphorylated by CK1.
• Cellular localizationCytoplasm. In neurons, axonally transported to the nerve terminals.

Target information above from: UniProt accession P27348 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 10971 Human
  • Omim: 609009 Human
  • SwissProt: P27348 Human
  • Unigene: 74405 Human

• Alternative names
  14 3 3 protein T cell antibody14 3 3 protein tau antibody14 3 3 protein theta antibody

  14 3 3 tau antibody14 3 3 theta antibody14-3-3 protein T-cell antibody14-3-3 protein tau antibody14-3-3 protein theta antibody1433T_HUMAN antibody1C5 antibodyHS1 antibodyKCIP1 antibodyProtein HS1 antibodyProtein kinase C inhibitor protein 1 antibodyProtein tau antibodytyr3/trp5 monooxygenase activation protein, theta antibodyTyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein, theta polypeptide antibodyYwhaq antibody

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Anti-14-3-3 Tau antibody [AT1A1] images

• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - 14-3-3 Tau antibody [AT1A1] (ab105326)
  ab105326, at 10 µg/ml, staining 14-3-3 Tau in formalin-fixed, paraffin-embedded Human Brain, Cortex by Immunohistochemistry, using a biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - 14-3-3 Tau antibody [AT1A1] (ab105326)
  ab105326, at 10 µg/ml, staining 14-3-3 Tau in formalin-fixed, paraffin-embedded Human Pancreas tissue by Immunohistochemistry, using a biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
• 

  Western blot - 14-3-3 Tau antibody [AT1A1] (ab105326)
  Anti-14-3-3 Tau antibody [AT1A1] (ab105326) at 1/1000 dilution + Jurkat cell lysate
  
  Predicted band size : 28 kDa