Overview

  • Product nameAnti-14-3-3 Tau antibodySee all 14-3-3 Tau primary antibodies ...
  • Description
    Rabbit polyclonal to 14-3-3 Tau
  • Tested applicationsICC/IF, ELISA more details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthesized non-phosphopeptide derived from human 14-3-3 Tau around the phosphorylation site of serine 232 (S-D-SP-A-G).

  • Positive control
    • HeLa cells

Properties

Applications

Our Abpromise guarantee covers the use of ab63630 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
ICC/IF 1/500 - 1/1000.
ELISA 1/5000.

Target

  • FunctionAdapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
  • Tissue specificityAbundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement.
  • Sequence similaritiesBelongs to the 14-3-3 family.
  • Post-translational
    modifications
    Ser-232 is probably phosphorylated by CK1.
  • Cellular localizationCytoplasm. In neurons, axonally transported to the nerve terminals.
  • Target information above from: UniProt accession P27348 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
  • Alternative names
    • 14 3 3 protein T cell antibody
    • 14 3 3 protein tau antibody
    • 14 3 3 protein theta antibody
    • 14 3 3 tau antibody
    • 14 3 3 theta antibody
    • 14-3-3 protein T-cell antibody
    • 14-3-3 protein tau antibody
    • 14-3-3 protein theta antibody
    • 1433T_HUMAN antibody
    • 1C5 antibody
    • HS1 antibody
    • KCIP1 antibody
    • Protein HS1 antibody
    • Protein kinase C inhibitor protein 1 antibody
    • Protein tau antibody
    • tyr3/trp5 monooxygenase activation protein, theta antibody
    • Tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein, theta polypeptide antibody
    • YWHAQ antibody
    see all

Anti-14-3-3 Tau antibody images

  • Immunofluorescence analysis of HeLa cells using ab63630 at a dilution of 1/500-1/1000. Samples were untreated (left hand panel) or treated (right hand panel) with the immunizing peptide.

References for Anti-14-3-3 Tau antibody (ab63630)

ab63630 has not yet been referenced specifically in any publications.

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