Anti-14-3-3 Tau antibody (ab77268)

Overview

• Product nameAnti-14-3-3 Tau antibodySee all 14-3-3 Tau primary antibodies ...
• Description
  Goat polyclonal to 14-3-3 Tau
• Tested applicationsWB, ELISA more details
• Species reactivity
  Reacts with: Human
  Predicted to work with: Mouse, Rat, Rabbit, Chicken, Cow, Pig, Xenopus laevis, Orangutan
• Immunogen

  Synthetic peptide: C-DDRKQTIDNSQ, corresponding to internal sequence amino acids 136-146 of Human 14-3-3 Tau (NP_006817.1).

  Run BLAST with Run BLAST with
• Positive controlHuman Brain (Hippocampus) lysate.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: 0.02% Sodium Azide
  Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
• Concentration information loading...
• PurityImmunogen affinity purified
• Purification notesab77268 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Stem Cells
  • Signaling Pathways
  • Wnt
  • 14-3-3

  • Signal Transduction
  • Adapters
  • Cytoplasmic

  • Neuroscience
  • Cell Type Marker
  • Neuron marker
  • Synapse marker

  • Neuroscience
  • Neurology process
  • Neural Signal Transduction

Applications

Target

• FunctionAdapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
• Tissue specificityAbundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement.
• Sequence similaritiesBelongs to the 14-3-3 family.
• Post-translational
  modificationsSer-232 is probably phosphorylated by CK1.
• Cellular localizationCytoplasm. In neurons, axonally transported to the nerve terminals.

Target information above from: UniProt accession P27348 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 768311 Cow
  • Entrez Gene: 10971 Human
  • Entrez Gene: 22630 Mouse
  • Entrez Gene: 25577 Rat
  • Omim: 609009 Human
  • SwissProt: Q5ZMD1 Chicken
  • SwissProt: Q3SZI4 Cow
  • SwissProt: P27348 Human

  • SwissProt: P68254 Mouse
  • SwissProt: P68255 Rat
  • SwissProt: Q52M98 Xenopus laevis
  • Unigene: 74405 Human
  • Unigene: 289630 Mouse
  • Unigene: 458320 Mouse
  • Unigene: 2502 Rat
  • Unigene: 46592 Xenopus laevis
  • Unigene: 74593 Xenopus laevis

  see all

• Alternative names
  14 3 3 protein T cell antibody14 3 3 protein tau antibody14 3 3 protein theta antibody

  14 3 3 tau antibody14 3 3 theta antibody14-3-3 protein T-cell antibody14-3-3 protein tau antibody14-3-3 protein theta antibody1433T_HUMAN antibody1C5 antibodyHS1 antibodyKCIP1 antibodyProtein HS1 antibodyProtein kinase C inhibitor protein 1 antibodyProtein tau antibodytyr3/trp5 monooxygenase activation protein, theta antibodyTyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein, theta polypeptide antibodyYWHAQ antibody

  see all

Anti-14-3-3 Tau antibody images

• 

  Western blot - 14-3-3 Tau antibody (ab77268)
  Anti-14-3-3 Tau antibody (ab77268) at 0.03 µg/ml + Human Brain (Hippocampus) in RIPA buffer at 35 µg
  
  Predicted band size : 28 kDa
  Observed band size : 28 kDa