Overview

  • Product nameAnti-14-3-3 Tau antibody
    See all 14-3-3 Tau primary antibodies
  • Description
    Goat polyclonal to 14-3-3 Tau
  • Tested applicationsWB, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Chicken, Cow, Pig, Xenopus laevis, Orangutan
  • Immunogen

    Synthetic peptide:

    C-DDRKQTIDNSQ

    , corresponding to internal sequence amino acids 136-146 of Human 14-3-3 Tau (NP_006817.1).

  • Positive control
    • Human Brain (Hippocampus) lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab77268 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
  • Application notesPeptide ELISA: Use at an assay dependent dilution. Antibody detection limit dilution 1/4,000.
    WB: Use at a concentration of 0.03 - 0.1 µg/ml. Detects a band of approximately 28 kDa (predicted molecular weight: 28 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionAdapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
    • Tissue specificityAbundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement.
    • Sequence similaritiesBelongs to the 14-3-3 family.
    • Post-translational
      modifications
      Ser-232 is probably phosphorylated by CK1.
    • Cellular localizationCytoplasm. In neurons, axonally transported to the nerve terminals.
    • Information by UniProt
    • Database links
    • Alternative names
      • 14 3 3 protein T cell antibody
      • 14 3 3 protein tau antibody
      • 14 3 3 protein theta antibody
      • 14 3 3 tau antibody
      • 14 3 3 theta antibody
      • 14-3-3 protein T-cell antibody
      • 14-3-3 protein tau antibody
      • 14-3-3 protein theta antibody
      • 1433T_HUMAN antibody
      • 1C5 antibody
      • HS1 antibody
      • KCIP1 antibody
      • Protein HS1 antibody
      • Protein kinase C inhibitor protein 1 antibody
      • Protein tau antibody
      • tyr3/trp5 monooxygenase activation protein, theta antibody
      • Tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein, theta polypeptide antibody
      • YWHAQ antibody
      see all

    Anti-14-3-3 Tau antibody images

    • Anti-14-3-3 Tau antibody (ab77268) at 0.03 µg/ml + Human Brain (Hippocampus) in RIPA buffer at 35 µg

      Predicted band size : 28 kDa
      Observed band size : 28 kDa

    References for Anti-14-3-3 Tau antibody (ab77268)

    ab77268 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"