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Overview

  • Product name14-3-3 Tau protein (Tagged)See all 14-3-3 Tau proteins and peptides ...
  • Protein descriptionRecombinant full-length human 14-3-3 Tau with an N-terminal tag.
  • Expression hostE. coli

    • Properties

  • Purity> 95 % by SDS-PAGE
  • Purification notesThe purity was determined to be >95% by densitometry.
  • FormLiquid
  • Storage instructionsShipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM PMSF, pH 7.5
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab70352 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    WB WB: Use at an assay dependent dilution. Detects a band of approximately 56 kDa.

    Protein info

    • Alternative names
        14 3 3 protein T cell14 3 3 protein tau14 3 3 protein theta
        14 3 3 tau14 3 3 theta14-3-3 protein T-cell14-3-3 protein tau14-3-3 protein theta1433T_HUMAN1C5HS1KCIP1Protein HS1Protein kinase C inhibitor protein 1Protein tautyr3/trp5 monooxygenase activation protein, thetaTyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein, theta polypeptideYWHAQ
      see all
  • FunctionAdapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
  • Tissue specificityAbundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement.
  • Sequence similaritiesBelongs to the 14-3-3 family.
  • Post-translational
    modifications    Ser-232 is probably phosphorylated by CK1.
  • Cellular localizationCytoplasm. In neurons, axonally transported to the nerve terminals.

    • Target information above from: UniProt accession P27348 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    14-3-3 Tau protein (Tagged) images

    • SDS-PAGE - 14-3-3 Tau protein (Tagged) (ab70352)
      SDS-PAGE - 14-3-3 Tau protein (Tagged) (ab70352)
      SDS-PAGE showing ab70532 14-3-3 Tau protein at approximately 56kDa.

    References for 14-3-3 Tau protein (Tagged) (ab70352)

    ab70352 has not yet been referenced specifically in any publications.

    Publishing research using ab70352 ? Please let us know so that we can cite the reference in this datasheet

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