Anti-14-3-3 beta + zeta antibody [4E2] (ab14114)

Overview

  • Product nameAnti-14-3-3 beta + zeta antibody [4E2]
    See all 14-3-3 beta + zeta primary antibodies
  • Description
    Mouse monoclonal [4E2] to 14-3-3 beta + zeta
  • Tested applicationsSuitable for: WB, ICCmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Sheep, Cow, Dog, Human, Pig, Monkey
  • Immunogen

    Tissue/ cell preparation (Lysed transformed human amnion cells).

  • Positive control
    • HeLa cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab14114 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 30 kDa.
ICC 1/50.

Target

  • Relevance14-3-3 proteins are highly conserved proteins which play a role in both signal transduction and progression through the cell cycle by binding to and regulating several different proteins. 14-3-3 proteins activate tyrosine and tryptophan hydroxylases and protein kinase C. They mediate signal transduction by binding to phosphoserine-containing proteins. There are at least 7 mammalian isoforms: alpha, beta, gamma, delta, epsilon, zeta, and eta. An eighth subtype, termed theta has been found in rat brain. The 14-3-3 proteins exists in vitro and in vivo as either homo- or heterodimers which interact via their N-terminal domains and are subject to phosphorylation by protein kinase C. 14-3-3 proteins are localized in the cytoplasm of neurons in the cerebral cortex and are axonally transported to the nerve terminals. They may be present at lower levels in various other eukaryotic tissues. Northern blot analysis has shown expression of the eta chain in cultured cell lines derived from various tumors.
  • Cellular localizationCytoplasmic. Melanosome (fractions from stage I to stage IV)
  • Database links
  • Alternative names
    • 14 3 3 protein beta antibody
    • 14 3 3 protein beta/alpha antibody
    • 14 3 3 protein zeta/delta antibody
    • 14 3 3 zeta antibody
    • HS1 antibody
    • KCIP1 antibody
    • YWHAB antibody
    • YWHAZ antibody
    see all

References for Anti-14-3-3 beta + zeta antibody [4E2] (ab14114)

ab14114 has not yet been referenced specifically in any publications.

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