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KMKGDYYRYLAE, corresponding to amino acids 124-135 of 14-3-3 eta + gamma + zeta.
14-3-3 proteins are 30kD polypeptides with nine closely related members in mammals. They are also found in plants and fungi. 14-3-3 proteins are a family of small, widely expressed, highly conserved cytosolic proteins which bind to and influence the activities of a diverse group of molecules involved in signal transduction, cell cycle regulation and apoptosis, including Raf, PKC, Bad, Cbl, and c-Bcr. Interactions between 14-3-3 and target proteins are strongly influenced by the phosphorylation state of 14-3-3 and the target protein. 14-3-3 proteins form homo- and hetero-dimeric cup-like structures that bind to discrete phosphoserine-containing motifs. In some instances, 14-3-3 proteins appear to export their binding partners from the nucleus to the cytoplasm in a phosphorylation and Crm1-dependent manner. At least seven isoforms of 14-3-3 have been identified with the zeta isoform being the most broadly expressed in animals.
Our Abpromise guarantee covers the use of ab14124 in the following tested applications.
|ELISA||Use at an assay dependent dilution.|
|WB||1/10000. Predicted molecular weight: 27 kDa.|
ab14124 has not yet been referenced specifically in any publications.