Anti-14-3-3 zeta antibody [1314CT423.108.153.173.140] (ab188368)

Overview

  • Product name
    Anti-14-3-3 zeta antibody [1314CT423.108.153.173.140]
    See all 14-3-3 zeta primary antibodies
  • Description
    Mouse monoclonal [1314CT423.108.153.173.140] to 14-3-3 zeta
  • Host species
    Mouse
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
    Predicted to work with: Cow
  • Immunogen

    Recombinant full length protein corresponding to Human 14-3-3 zeta aa 1-245.
    Database link: P63104

  • Positive control
    • A431, HepG2, NIH-3T3, PC-12, C6 and Mouse brain lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab188368 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 28 kDa.

Target

  • Function
    Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
  • Sequence similarities
    Belongs to the 14-3-3 family.
  • Post-translational
    modifications
    The delta, brain-specific form differs from the zeta form in being phosphorylated (By similarity). Phosphorylation on Ser-184 by MAPK8; promotes dissociation of BAX and translocation of BAX to mitochondria. Phosphorylation on Ser-58 by PKA; disrupts homodimerization and heterodimerization with YHAE and TP53. This phosphorylation appears to be activated by sphingosine. Phosphorylation on Thr-232; inhibits binding of RAF1.
  • Cellular localization
    Cytoplasm. Melanosome. Located to stage I to stage IV melanosomes.
  • Information by UniProt
  • Database links
  • Alternative names
    • 14 3 3 delta antibody
    • 14 3 3 protein zeta/delta antibody
    • 14 3 3 protein/cytosolic phospholipase A2 antibody
    • 14 3 3 zeta antibody
    • 14-3-3 protein zeta/delta antibody
    • 1433Z_HUMAN antibody
    • Epididymis luminal protein 4 antibody
    • Epididymis secretory protein Li 3 antibody
    • HEL S 3 antibody
    • HEL4 antibody
    • KCIP-1 antibody
    • KCIP1 antibody
    • MGC111427 antibody
    • MGC126532 antibody
    • MGC138156 antibody
    • Phospholipase A2 antibody
    • Protein kinase C inhibitor protein 1 antibody
    • Tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein, delta polypeptide antibody
    • Tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein, zeta antibody
    • Tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein, zeta polypeptide antibody
    • Tyrosine 3/tryptophan 5 monooxygenase activation protein, zeta polypeptide antibody
    • YWHAD antibody
    • YWHAZ antibody
    see all

Images

  • All lanes : Anti-14-3-3 zeta antibody [1314CT423.108.153.173.140] (ab188368) at 1/1000 dilution

    Lane 1 : A431 cell lysate
    Lane 2 : HepG2 cell lysate
    Lane 3 : NIH-3T3 cell lysate
    Lane 4 : PC-12 cell lysate
    Lane 5 : C6 cell lysate
    Lane 6 : Mouse brain tissue lysate

    Lysates/proteins at 35 µg per lane.

    Secondary
    All lanes : Goat anti-mouse IgG H&L(HRP) at 1/5000 dilution

    Predicted band size: 28 kDa

References

ab188368 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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