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Read our guarantee »Overview
Product name
1400W
Description
Selective iNOS inhibitor
Biological description
Selective iNOS inhibitor, 5000-fold selective over eNOS (Kd values are ≤7 nM, 2 µM and 50 µM at human iNOS, nNOS and eNOS respectively).
Purity
> 99%
General notes
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Properties
Chemical name
N-(3-(Aminomethyl)benzyl)acetamidine dihydrochloride
Molecular Weight
250.17
Chemical structure
Molecular formula
C10H15N3.2HCl
CAS Number
180001-34-7
Solubility
Soluble in water to 100 mM
Storage instructions
Store at +4°C (desiccating conditions). Do not freeze.
Research areas
Biochemicals >> Research Area >> Stroke >> Signaling >> Nitric Oxide >> NOS >> Inhibitors
Biochemicals >> Research Area >> Respiratory disease >> Signaling >> Nitric Oxide >> NOS >> Inhibitors
Biochemicals >> Research Area >> Pain & inflammation >> Signaling >> Nitric Oxide >> NOS >> Inhibitors
Biochemicals >> Research Area >> Obesity >> Signaling >> Nitric Oxide >> NOS >> Inhibitors
Biochemicals >> Research Area >> Hypertension >> Signaling >> Nitric Oxide >> NOS >> Inhibitors
Biochemicals >> Research Area >> Heart disease >> Signaling >> Nitric Oxide >> NOS >> Inhibitors
Biochemicals >> Research Area >> Diabetes >> Signaling >> Nitric Oxide >> NOS >> Inhibitors
Biochemicals >> Research Area >> Cancer >> Signaling >> Nitric Oxide >> NOS >> Inhibitors
Biochemicals >> Research Area >> Alzheimer's Disease >> Signaling >> Nitric Oxide >> NOS >> Inhibitors
Biochemicals >> Pharmacology >> Signaling >> Nitric Oxide >> NOS >> Inhibitors
Biochemicals >> Pharmacology >> Enzymes >> Synthetase & synthase >> Inhibitors
Biochemicals >> Chemical Type >> Biochemicals
Biochemicals >> Product Range >> Just Add Water
References for 1400W (ab120165)
This product has been referenced in:
- Hamilton LC & Warner TD Interactions between inducible isoforms of nitric oxide synthase and cyclo-oxygenase in vivo: investigations using the selective inhibitors, 1400W and celecoxib. Br J Pharmacol 125:335-40 (1998).Read more (PubMed: 9786506) »
- Garvey EP et al. 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J Biol Chem 272:4959-63 (1997).Read more (PubMed: 9030556) »
See all 3 publications for this product
Publishing research using ab120165? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"