Overview

  • Product name
    2-Methoxyantimycin A3
  • Description
    Bcl-xL and Bcl-2 inhibitor. Apoptotic.
  • Biological description
    Bcl-xL and Bcl-2 inhibitor. Antiapoptotic. Depolarizes mitochrondrial membrane potential. Reduces tumor size in vivo without toxicity.
  • Purity
    > 98%

Properties

  • Chemical name
    2-Methoxyantimycin A3
  • Molecular weight
    534.60
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C27H38N2O9
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO to 10 mM and in ethanol to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    O=CNc1cccc(c1OC)C(=O)N[C@@H]2C(=O)O[C@@H](C)[C@H](OC(=O)CC(C)C)[C@@H](CCCC)C(=O)O[C@@H]2C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Cao X  et al. Bcl2/bcl-xL inhibitor engenders apoptosis and increases chemosensitivity in mesothelioma. Cancer Biol Ther 6:246-52 (2007). Read more (PubMed: 17224645) »
  • Schwartz PS  et al. 2-Methoxy antimycin reveals a unique mechanism for Bcl-x(L) inhibition. Mol Cancer Ther 6:2073-80 (2007). Read more (PubMed: 17620436) »
  • Shangary S & Johnson DE Recent advances in the development of anticancer agents targeting cell death inhibitors in the Bcl-2 protein family. Leukemia 17:1470-81 (2003). Read more (PubMed: 12886234) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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