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AbcamBiochemicals (Asc-653)

2-Methoxyestradiol (ab120653)

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Overview

  • Product name2-Methoxyestradiol
  • Description
    Potent antitumor and antiangiogenic agent
  • Biological descriptionPotent antioxidant. Inhibits angiogenesis in vivo with direct cytotoxic effects seen in vitro. Interacts with endothelial tubulin dynamics and increases the expression of death receptor 5 in endothelial cells. Induces apoptosis by p53 induction via activation of p38/JNK pathways.
  • Purity> 98%

    • Properties

  • Chemical name(17β)-2-Methoxyestra-1,3,5(10)-triene-3,17-diol
  • Molecular Weight302.41
  • Chemical structureChemical Structure
  • Molecular formulaC19H26O3
  • CAS Number362-07-2
  • Storage instructionsStore at room temperature.
  • Handling

    Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

  • Source

    Synthetic

  • Research Areas

    • References for 2-Methoxyestradiol (ab120653)

    This product has been referenced in:
    • Dubey RK & Jackson EK Potential vascular actions of 2-methoxyestradiol. Trends Endocrinol Metab 20:374-9 (2009). Read more (PubMed: 19734053) »
    • Davoodpour P & Landström M 2-Methoxyestradiol-induced apoptosis in prostate cancer cells requires Smad7. J Biol Chem 280:14773-9 (2005). Read more (PubMed: 15708859) »
    • LaVallee TM  et al. 2-methoxyestradiol up-regulates death receptor 5 and induces apoptosis through activation of the extrinsic pathway. Cancer Res 63:468-75 (2003). Read more (PubMed: 12543804) »
    • Shimada K  et al. Roles of p38- and c-jun NH2-terminal kinase-mediated pathways in 2-methoxyestradiol-induced p53 induction and apoptosis. Carcinogenesis 24:1067-75 (2003). Read more (PubMed: 12807754) »

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"