Overview

  • Product name2-Methoxyestradiol
  • Description
    Potent antitumor and antiangiogenic agent
  • Biological descriptionPotent antioxidant. Inhibits angiogenesis in vivo with direct cytotoxic effects seen in vitro. Interacts with endothelial tubulin dynamics and increases the expression of death receptor 5 in endothelial cells. Induces apoptosis by p53 induction via activation of p38/JNK pathways.
  • Purity> 98%

Properties

    References for 2-Methoxyestradiol (ab120653)

    This product has been referenced in:
    • Dubey RK & Jackson EK Potential vascular actions of 2-methoxyestradiol. Trends Endocrinol Metab 20:374-9 (2009). Read more (PubMed: 19734053) »
    • Davoodpour P & Landström M 2-Methoxyestradiol-induced apoptosis in prostate cancer cells requires Smad7. J Biol Chem 280:14773-9 (2005). Read more (PubMed: 15708859) »
    • LaVallee TM  et al. 2-methoxyestradiol up-regulates death receptor 5 and induces apoptosis through activation of the extrinsic pathway. Cancer Res 63:468-75 (2003). Read more (PubMed: 12543804) »
    • Shimada K  et al. Roles of p38- and c-jun NH2-terminal kinase-mediated pathways in 2-methoxyestradiol-induced p53 induction and apoptosis. Carcinogenesis 24:1067-75 (2003). Read more (PubMed: 12807754) »

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