Overview

  • Product name
    2-APB
  • Description
    Ca2+ release modulator
  • Biological description
    Cell-permeable, allosteric inhibitor of D-myo-inositol 1,4,5-trisphosphate (IP3) -induced Ca2+ release . Inhibits IP3-induced Ca2+ release without affecting IP3 receptor binding. Blocks store operated Ca2+ entry.
  • Purity
    > 98%

Properties

References

This product has been referenced in:
  • Peppiatt CM  et al. 2-Aminoethoxydiphenyl borate (2-APB) antagonises inositol 1,4,5-trisphosphate-induced calcium release, inhibits calcium pumps and has a use-dependent and slowly reversible action on store-operated calcium entry channels. Cell Calcium 34:97-108 (2003). Read more (PubMed: 12767897) »
  • Bilmen JG & Michelangeli F Inhibition of the type 1 inositol 1,4,5-trisphosphate receptor by 2-aminoethoxydiphenylborate. Cell Signal 14:955-60 (2002). Read more (PubMed: 12220621) »
  • Maruyama T  et al. 2APB, 2-aminoethoxydiphenyl borate, a membrane-penetrable modulator of Ins(1,4,5)P3-induced Ca2+ release. J Biochem 122:498-505 (1997). Read more (PubMed: 9348075) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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