Biological descriptionEndogenous potent CB1 agonist (EC50 values are 519 and 618 nM at CB1 and CB2, respectively). Agonist activity also seen at GPR55 orphan receptor (EC50 = 3 nM). Able to induce a rapid and transient increases in intracellular Ca2+ concentrations in vitro. Abundantly expressed in the brain.
Chemical name(5Z,8Z,11Z,14Z)-Eicosatetraenoic-5,6,8,9,11,12,14,15-d8 acid 2-glyceryl ester
Storage instructionsStore at -80°C.
Solubility overviewSupplied in acetonitrile (100 µg/ml)
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
References for 2-Arachidonoyl glycerol-d8 (ab120919)
This product has been referenced in:
Sugiura T et al. Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells. J Biol Chem275:605-12 (2000).
Read more (PubMed: 10617657) »
Sugiura T et al. Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor. Structure-activity relationship of 2-arachidonoylglycerol, ether-linked analogues, and related compounds. J Biol Chem274:2794-801 (1999).
Read more (PubMed: 9915812) »
Kondo S et al. 2-Arachidonoylglycerol, an endogenous cannabinoid receptor agonist: identification as one of the major species of monoacylglycerols in various rat tissues, and evidence for its generation through CA2+-dependent and -independent mechanisms. FEBS Lett429:152-6 (1998).
Read more (PubMed: 9650580) »