Overview

  • Product name
    2-Furoyl-LIGRLO-amide (2Fly)
  • Description
    Potent and selective PAR2 agonist
  • Alternative names
    • 2Fly
  • Biological description
    Potent and selective PAR2 receptor agonist (EC50 = 340 nM). Induces arterial contraction. Facilitates capsaicin evoked nociception. Around 100 times more potent than SLIGR-NH2 (ab120176).
  • Purity
    > 95%

Properties

  • Molecular weight
    777.96
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C36H63N11O8
  • CAS Number
    729589-58-6
  • Sequence
    LIGRLX (Modifications: N-terminal 2-Furoyl; C-terminal amide; X-6 = Orn)
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in water to 1 mg/ml
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Hollenberg MD  et al. Derivatized 2-furoyl-LIGRLO-amide, a versatile and selective probe for proteinase-activated receptor 2: binding and visualization. J Pharmacol Exp Ther 326:453-62 (2008). Read more (PubMed: 18477767) »
  • Saifeddine M  et al. Proteinase-activated receptor-2 activating peptides: distinct canine coronary artery receptor systems. Am J Physiol Heart Circ Physiol 293:H3279-89 (2007). Read more (PubMed: 17766477) »
  • Kawabata A  et al. Colonic hyperalgesia triggered by proteinase-activated receptor-2 in mice: involvement of endogenous bradykinin. Neurosci Lett 402:167-72 (2006). Read more (PubMed: 16644120) »
  • McGuire JJ  et al. 2-furoyl-LIGRLO-amide: a potent and selective proteinase-activated receptor 2 agonist. J Pharmacol Exp Ther 309:1124-31 (2004). Read more (PubMed: 14976230) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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