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Product name
2,3-Butanedione 2-monoxime (BDM)
Description
Non-selective myosin ATPase inhibitor
Alternative names
- BDM
- Biacetyl monoxime
- Diacetyl monoxime
Biological description
Non-selective myosin ATPase inhibitor (Ki = 5 mM at myosin II). Potent Kv2.1 (DRK1) and L-Type Ca2+ channel inhibitor (Ki and IC50 values are 10.7 nM and 5.8 mM respectively). Blood brain barrier permeable. Inhibits muscle contraction.
General notes
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Properties
Chemical name
2,3-Butanedione monoxime
Molecular Weight
101.10
Chemical structure
Molecular formula
C4H7NO2
CAS Number
57-71-6
Solubility
Soluble in water to 100 mM
Storage instructions
Store at room temperature (desiccating conditions).
Research areas
Biochemicals >> Pharmacology >> Enzymes >> ATPase & GTPase >> Inhibitors
Biochemicals >> Pharmacology >> Ion Channels >> Potassium >> Blockers
Biochemicals >> Chemical Type >> Biochemicals
References for 2,3-Butanedione 2-monoxime (BDM) (ab120616)
This product has been referenced in:
- Wang DQ et al. Heterogeneity of Hanganutziu-Deicher antigen glycoproteins in different species animal sera. Nihon Juigaku Zasshi 52:567-72 (1990).Read more (PubMed: 1696647) »
- Kabelka M & Horák J Pneumomediastinography in the diagnosis of ectopic lobe of the thymus in respiratory obstruction. J Pediatr Surg 11:265-6 (1976).Read more (PubMed: 1263070) »
See all 6 publications for this product
Publishing research using ab120616? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"