2',3'-Dideoxycytidine (ddC), nucleoside reverse transcriptase inhibitor (NRTI) (ab142240)
Key features and details
- Nucleoside reverse transcriptase inhibitor (NRTI)
- CAS Number: 7481-89-2
- Purity: > 99%
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
2',3'-Dideoxycytidine (ddC), nucleoside reverse transcriptase inhibitor (NRTI) -
Description
Nucleoside reverse transcriptase inhibitor (NRTI) -
Alternative names
- ddC
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Biological description
Nucleoside reverse transcriptase inhibitor (NRTI). Pyrimidine nucleoside analog, substrate for reverse transcriptase. Able to induce oxidative stress. Effective against HIV replication in vivo.
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Purity
> 99% -
CAS Number
7481-89-2 -
Chemical structure
Properties
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Chemical name
4-Amino-1-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one -
Molecular weight
211.22 -
Molecular formula
C9H13N3O3 -
PubChem identifier
24066 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1CC(OC1CO)N2C=CC(=NC2=O)N -
Source
Synthetic
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Research areas
Images
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (3)
ab142240 has been referenced in 3 publications.
- Zimyanin VL et al. Live Cell Imaging of ATP Levels Reveals Metabolic Compartmentalization within Motoneurons and Early Metabolic Changes in FUS ALS Motoneurons. Cells 12:N/A (2023). PubMed: 37408187
- Weindel CG et al. Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis. Cell 185:3214-3231.e23 (2022). PubMed: 35907404
- Wagner AR et al. SRSF6 balances mitochondrial-driven innate immune outcomes through alternative splicing of BAX. Elife 11:N/A (2022). PubMed: 36409059