Overview

  • Product name
    25-Hydroxycholesterol
  • Description
    Biologically active cholesterol metabolite
  • Alternative names
    • 25-HC
    • 25-hydroxy-cholesterol
    • 25-OHC
    • Cholest-5-ene-3beta,25-diol
    • oxysterol
    see all
  • Biological description

    Cholesterol metabolite produced and secreted by macrophages in response to TLR activation. Regulates immune function and has a key role in the pathogenesis of atherosclerosis.

Properties

  • Molecular weight
    402.65
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C27H46O2
  • CAS Number
    2140-46-7
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CC(C)(O)CCC[C@@H](C)[C@H]4CC[C@@H]3[C@]4(C)CC[C@H]2[C@H]3CC=C1C[C@@H](O)CC[C@@]12C
  • Source

    Synthetic

References

This product has been referenced in:
  • Cyster JG  et al. 25-Hydroxycholesterols in innate and adaptive immunity. Nat Rev Immunol 14:731-43 (2014). Read more (PubMed: 25324126) »
  • Diczfalusy U On the formation and possible biological role of 25-hydroxycholesterol. Biochimie 95:455-60 (2013). Read more (PubMed: 22732193) »
  • Wang F  et al. Interferon regulator factor 1/retinoic inducible gene I (IRF1/RIG-I) axis mediates 25-hydroxycholesterol-induced interleukin-8 production in atherosclerosis. Cardiovasc Res 93:190-9 (2012). Read more (PubMed: 21979142) »
  • McDonald JG & Russell DW Editorial: 25-Hydroxycholesterol: a new life in immunology. J Leukoc Biol 88:1071-2 (2010). Read more (PubMed: 21123296) »
  • Bauman DR  et al. 25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production. Proc Natl Acad Sci U S A 106:16764-9 (2009). Read more (PubMed: 19805370) »

See 0 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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