Overview

  • Product name
    (2S)-2-Hydroxyglutaric acid
  • Description
    α-ketoglutarate-dependent dioxygenase competitive inhibitor
  • Alternative names
    • (2S)-2-Hydroxypentanedioic Acid
    • L-2-HG
    • L-2-Hydroxyglutarate
    • L-2-Hydroxyglutaric Acid
  • Biological description

    α-hydroxy acid. Normally metabolized to 2-oxoglutarate (α-ketoglutarate) by L-2-hydroxyglutarate dehydrogenases, and mutations in this enzyme cause L-2-hydroxyglutaric aciduria, a neurometabolic disorder. Structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including lysine demethylases and DNA hydroxylases.

  • Purity
    > 95%

Properties

  • Chemical name
    (S)-2-Hydroxypentanedioic acid
  • Molecular weight
    148.11
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C5H8O5
  • CAS Number
    13095-48-2
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:
  • da Rosa MS  et al. In vivo intracerebral administration of L-2-hydroxyglutaric acid provokes oxidative stress and histopathological alterations in striatum and cerebellum of adolescent rats. Free Radic Biol Med 83:201-13 (2015). Read more (PubMed: 25701435) »
  • Xu W  et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of a-ketoglutarate-dependent dioxygenases. Cancer Cell 19:17-30 (2011). Read more (PubMed: 21251613) »
  • Chowdhury R  et al. The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases. EMBO Rep 12:463-9 (2011). Read more (PubMed: 21460794) »
  • Rzem R  et al. A gene encoding a putative FAD-dependent L-2-hydroxyglutarate dehydrogenase is mutated in L-2-hydroxyglutaric aciduria. Proc Natl Acad Sci U S A 101:16849-54 (2004). Read more (PubMed: 15548604) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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