Overview

  • Product nameAnti-4 Hydroxynonenal antibody
    See all 4 Hydroxynonenal primary antibodies
  • Description
    Goat polyclonal to 4 Hydroxynonenal
  • SpecificityThis antibody specifically binds to HNE modified proteins.
  • Tested applicationsSuitable for: IHC-Fr, ELISA, WBmore details
  • Immunogen

    HNE conjugated to KLH

Properties

Applications

Our Abpromise guarantee covers the use of ab46544 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-Fr Use at an assay dependent concentration. PubMed: 24932583
ELISA 1/4000 - 1/32000.
WB 1/4000 - 1/32000. Predicted molecular weight: 10 kDa.

Target

  • RelevanceAldehydic products of lipid peroxidation, such as 4 hydroxynonenal (4 HNE), have been implicated in the etiology of pathological changes under oxidative stress as a key mediator of oxidative stress induced cell death. It is a stable product of lipid peroxidation, is proarrhythmic and may contribute to the cytotoxic effects of oxidative stress.
  • Cellular localizationCytoplasmic
  • Alternative names
    • 4 HNE antibody
    • 4-Hydroxy-2-Nonenal antibody

References for Anti-4 Hydroxynonenal antibody (ab46544)

This product has been referenced in:
  • Smuder AJ  et al. Cervical spinal cord injury exacerbates ventilator-induced diaphragm dysfunction. J Appl Physiol (1985) 120:166-77 (2016). Read more (PubMed: 26472866) »
  • Calamaras TD  et al. The lipid peroxidation product 4-hydroxy-trans-2-nonenal causes protein synthesis in cardiac myocytes via activated mTORC1-p70S6K-RPS6 signaling. Free Radic Biol Med 82:137-46 (2015). Read more (PubMed: 25617592) »

See all 9 Publications for this product

Product Wall

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We unfortunately don’t have the blocking peptide-like product to pre-absorb this goat polyclonal HNE antibody to test the specificity of the antibody.

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Thank you for calling Abcam yesterday.

The antibody, goat anti-HNE (ab46544) will recognize proteins that have been modified with HNE. The protein size of band is depended on the size of the modified protein.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"