Lipid peroxidation product, actively modifies histidine and lysine residues on proteins and causes protein cross-linking. Shows a variety of biological activities and is a TRPA1 activator (EC50 = 1.9 µM). Active in vivo.
Store at -80°C.
Supplied in methyl acetate (5 mg/ml)
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Näsström T et al. The lipid peroxidation products 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote the formation of a-synuclein oligomers with distinct biochemical, morphological, and functional properties. Free Radic Biol Med50:428-37 (2011).
Read more (PubMed: 21130160) »
Graepel R et al. 4-oxo-2-nonenal (4-ONE): evidence of transient receptor potential ankyrin 1-dependent and -independent nociceptive and vasoactive responses in vivo. J Pharmacol Exp Ther337:117-24 (2011).
Read more (PubMed: 21205926) »
Lee SH & Blair IA Characterization of 4-oxo-2-nonenal as a novel product of lipid peroxidation. Chem Res Toxicol13:698-702 (2000).
Read more (PubMed: 10956056) »