Overview

  • Product name
    4-P-PDOT
  • Description
    MT2 selective melatonin receptor antagonist
  • Biological description
    MT2 selective melatonin receptor antagonist (Ki values are 0.46 and 56 nM for MT2 and MT1 respectively). Counteracts melatonin-mediated ERK- and Nrf2-related antioxidant potential in vivo. Centrally active.
  • Purity
    > 99%

Properties

  • Chemical name
    N-(1,2,3,4-Tetrahydro-4-phenyl-2-naphthalenyl)propanamide
  • Molecular weight
    279.38
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C19H21NO
  • CAS Number
    134865-74-0
  • PubChem identifier
    3976006
  • Storage instructions
    Store at room temperature.
  • Solubility overview
    Soluble in ethanol to 100 mM and in DMSO to 100 mM
  • Handling

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CCC(=O)NC1CC(C2=CC=CC=C2C1)C3=CC=CC=C3
  • Source

    Synthetic

References

This product has been referenced in:
  • Shin EJ  et al. Melatonin attenuates memory impairment induced by Klotho gene deficiency via interactive signaling between MT2 receptor, ERK, and Nrf2-related antioxidant potential. Int J Neuropsychopharmacol 18: (2015). Read more (PubMed: 25550330) »
  • Juszczak M  et al. The influence od melatonin receptors antagonists, luzindole and 4-phenyl-2-propionamidotetralin (4-P-PDOT), on melatonin-dependent vasopressin and adrenocorticotropic hormone (ACTH) release from the rat hypothalamo-hypophysial system. In vitro and in vivo studies. J Physiol Pharmacol 65:777-84 (2014). Read more (PubMed: 25554981) »
  • Wang WW  et al. Abnormal response of the proliferation and differentiation of growth plate chondrocytes to melatonin in adolescent idiopathic scoliosis. Int J Mol Sci 15:17100-14 (2014). Read more (PubMed: 25257530) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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