5-Aza-2'-deoxycytidine (Decitabine) (ab120842)

Overview

  • Product name
    5-Aza-2'-deoxycytidine (Decitabine)
  • Description
    Potent DNMT1 inhibitor. Induces DNA hypomethylation.
  • Alternative names
    • 5-AzadCyD
    • Dacogen
    • Decitabine
    • NSC 127716
  • Biological description
    Potent DNA methyltransferase 1 (DNMT1) inhibitor (IC50 = 0.2 μM). Incorporated into DNA, inhibits DNMT1 activity to induce DNA hypomethylation. Interferes with protein synthesis. Shows antimetabolic and anticancer activities in vitro. Active in vivo.
  • Purity
    > 99%

Properties

References

This product has been referenced in:
  • Shin DY  et al. Decitabine, a DNA methyltransferase inhibitor, induces apoptosis in human leukemia cells through intracellular reactive oxygen species generation. Int J Oncol 41:910-8 (2012). Read more (PubMed: 22767021) »
  • Rodríguez-Reyes R & Morales-Ramírez P The in vivo induction of sister chromatid exchange by the demethylating agent 5-aza-2'-deoxycytidine. Mutagenesis 26:551-4 (2011). Read more (PubMed: 21454325) »
  • Liu QY  et al. Decitabine, independent of apoptosis, exerts its cytotoxic effects on cell growth in melanoma cells. Environ Toxicol Pharmacol 32:423-9 (2011). Read more (PubMed: 22004962) »
  • Cortvrindt R  et al. 5-Azacytidine and 5-aza-2'-deoxycytidine behave as different antineoplastic agents in B16 melanoma. Br J Cancer 56:261-5 (1987). Read more (PubMed: 2444244) »

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