Overview

  • Product name
    5-hmC (5-Hydroxymethylcytosine)
  • Description
    Novel DNA pyrimidine nitrogen base
  • Biological description
    Novel DNA pyrimidine nitrogen base. Initiates DNA demethylation. 5-Methylcytosine (ab145606) oxidation product. Epigenetic modifier in vivo.

Properties

  • Chemical name
    6-Amino-5-(hydroxymethyl)-1H-pyrimidin-2-one
  • Molecular weight
    141.13
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C5H7N3O2
  • CAS Number
    1123-95-1
  • PubChem identifier
    70751
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    C1=NC(=O)NC(=C1CO)N
  • Source

    Synthetic

References

This product has been referenced in:
  • Ficz G New insights into mechanisms that regulate DNA methylation patterning. J Exp Biol 218:14-20 (2015). Read more (PubMed: 25568447) »
  • Guo JU  et al. Genome-wide antagonism between 5-hydroxymethylcytosine and DNA methylation in the adult mouse brain. Front Biol (Beijing) 9:66-74 (2014). Read more (PubMed: 25568643) »
  • Tahiliani M  et al. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 324:930-5 (2009). Read more (PubMed: 19372391) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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