Overview

  • Product name5-Iodo A85380 dihydrochloride
  • Description
    Potent α4β2 and α6β2 receptor agonist
  • Biological descriptionPotent α4β2 and α6β2 receptor agonist (Ki = 0.2 nM at α4β2). 850 and 27000-fold more potent at α4β2 than α3β4 and α7, respectively. Shows antidepressant effects. Active in vivo.
  • Purity> 98%

Properties

  • Chemical name3-[(2S)-2-Azetidinylmethoxy]-5-iodopyridine dihydrochloride
  • Molecular weight363.03
  • Chemical structureChemical Structure
  • Molecular formulaC9H11IN2O.2HCl
  • CAS Number1217837-17-6
  • Storage instructionsStore at +4°C. Store under Desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overviewSoluble in water to 100 mM and DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILESCl.Cl.Ic1cc(cnc1)OC[C@@H]2CCN2
  • Source

    Synthetic

  • Research areas

    References for 5-Iodo A85380 dihydrochloride (ab120599)

    This product has been referenced in:
    • Caldarone BJ  et al. Dissociation between duration of action in the forced swim test in mice and nicotinic acetylcholine receptor occupancy with sazetidine, varenicline, and 5-I-A85380. Psychopharmacology (Berl) 217:199-210 (2011). Read more (PubMed: 21487659) »
    • Mogg AJ  et al. Functional responses and subunit composition of presynaptic nicotinic receptor subtypes explored using the novel agonist 5-iodo-A-85380. Neuropharmacology 47:848-59 (2004). Read more (PubMed: 15527819) »
    • Mukhin AG  et al. 5-Iodo-A-85380, an alpha4beta2 subtype-selective ligand for nicotinic acetylcholine receptors. Mol Pharmacol 57:642-9 (2000). Read more (PubMed: 10692507) »

    See 0 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"