Biological descriptionPotent α4β2 and α6β2 receptor agonist (Ki = 0.2 nM at α4β2). 850 and 27000-fold more potent at α4β2 than α3β4 and α7, respectively. Shows antidepressant effects. Active in vivo.
Chemical name3-[(2S)-2-Azetidinylmethoxy]-5-iodopyridine dihydrochloride
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 100 mM and DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
References for 5-Iodo A85380 dihydrochloride (ab120599)
This product has been referenced in:
Caldarone BJ et al. Dissociation between duration of action in the forced swim test in mice and nicotinic acetylcholine receptor occupancy with sazetidine, varenicline, and 5-I-A85380. Psychopharmacology (Berl)217:199-210 (2011).
Read more (PubMed: 21487659) »
Mogg AJ et al. Functional responses and subunit composition of presynaptic nicotinic receptor subtypes explored using the novel agonist 5-iodo-A-85380. Neuropharmacology47:848-59 (2004).
Read more (PubMed: 15527819) »
Mukhin AG et al. 5-Iodo-A-85380, an alpha4beta2 subtype-selective ligand for nicotinic acetylcholine receptors. Mol Pharmacol57:642-9 (2000).
Read more (PubMed: 10692507) »