• Product name
    Anti-5 Lipoxygenase antibody
    See all 5 Lipoxygenase primary antibodies
  • Description
    Rabbit polyclonal to 5 Lipoxygenase
  • Specificity
    ab59341 detects endogenous levels of total 5 lipoxygenase protein.
  • Tested applications
    Suitable for: WB, IHC-P, ELISAmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthesized non phosphopeptide derived from human 5 lipoxygenase around the phosphorylation site of serine 271 (QLSPLE).

  • Positive control
    • Human skeletal muscle tissue (IHC) HuvEc cytoplasmic lysate (WB)
  • General notes
    Store at -20° for 1 year



Our Abpromise guarantee covers the use of ab59341 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 78 kDa.
IHC-P Use at an assay dependent concentration.
ELISA 1/10000.


  • Function
    Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.
  • Pathway
    Lipid metabolism; leukotriene A4 biosynthesis.
  • Sequence similarities
    Belongs to the lipoxygenase family.
    Contains 1 lipoxygenase domain.
    Contains 1 PLAT domain.
  • Post-translational
    Serine phosphorylation by MAPKAPK2 is stimulated by arachidonic acid. Phosphorylation on Ser-523 by PKA has an inhibitory effect. Phosphorylation on Ser-272 prevents export from the nucleus.
  • Cellular localization
    Cytoplasm. Nucleus matrix. Nucleus membrane. Shuttles between cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated on Ser-272. Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association.
  • Information by UniProt
  • Database links
  • Alternative names
    • 5 LO antibody
    • 5 LOX antibody
    • 5-lipoxygenase antibody
    • 5-LO antibody
    • 5-LOX antibody
    • 5LOX antibody
    • 5LPG antibody
    • ALOX 5 antibody
    • Alox5 antibody
    • Arachidonate 5 lipoxygenase antibody
    • Arachidonate 5-lipoxygenase antibody
    • arachidonic 5-lipoxygenase alpha-10 isoform antibody
    • arachidonic 5-lipoxygenase delta-10-13 isoform antibody
    • arachidonic 5-lipoxygenase delta-13 isoform antibody
    • arachidonic 5-lipoxygenase delta-p10 isoform antibody
    • Arachidonic acid 5 lipoxygenase antibody
    • Leukotriene A4 synthase antibody
    • LOG 5 antibody
    • LOG5 antibody
    • LOX5_HUMAN antibody
    • MGC163204 antibody
    see all


  • All lanes : Anti-5 Lipoxygenase antibody (ab59341) at 1/500 dilution

    Lane 1 : Extracts from HuvEc cells without immunizing peptide
    Lane 2 : Extracts from HuvEc cells containing immunizing peptide

    Observed band size : 78 kDa (why is the actual band size different from the predicted?)
  • ab59341, at a 1/50 dilution, staining human 5 Lipoxygenase in skeletal muscle in the presence and absence of the immunizing peptide, using Immunohistochemistry, Paraffin embedded tissue.


This product has been referenced in:
  • Molina-Berríos A  et al. Protective role of acetylsalicylic acid in experimental Trypanosoma cruzi infection: evidence of a 15-epi-lipoxin A4-mediated effect. PLoS Negl Trop Dis 7:e2173 (2013). WB ; Mouse . Read more (PubMed: 23638194) »
  • Jun JI & Lau LF The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing. Nat Cell Biol 12:676-85 (2010). WB ; Human . Read more (PubMed: 20526329) »

See all 2 Publications for this product

Customer reviews and Q&As

Te pido disculpas por la espera.

He confirmado con mis compañeros del laboratorio que la proteína ab114310 puede también utilizarse como control positivo para el anticuerpo ab59341.

Si tuvieras cualquier otra consulta no dudes en co...

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