Overview

  • Product name
    5-Methyltryptamine hydrochloride
  • Description
    5-HT agonist
  • Biological description
    5-HT receptor agonist. Weak partial agonist at 5-HT3 (EC50 = 60 μM). (Ki values are 11 and 7.7 μM (as measured by inhibition of [3H] granisetron binding to 5-HT3A and 5-HT3AB receptors, respectively). Shows some selectivity for 5-HT2C over other 5-HT2 subtypes. 5-HT1C agonist.
  • Purity
    > 99%

Properties

References

This product has been referenced in:
  • Bower KS  et al. 5-Fluorotryptamine is a partial agonist at 5-HT3 receptors, and reveals that size and electronegativity at the 5 position of tryptamine are critical for efficient receptor function. Eur J Pharmacol 580:291-7 (2008). Read more (PubMed: 18082160) »
  • Tolloczko B  et al. Serotonin-evoked calcium transients in airway smooth muscle cells. Am J Physiol 269:L234-40 (1995). Read more (PubMed: 7653586) »
  • Watts SW & Cohen ML Further evidence that the guinea pig tracheal contractile serotonergic receptor is a 5-hydroxytryptamine2 receptor: use of 5-methyltryptamine and dipropyl-5-carboxamidotryptamine. J Pharmacol Exp Ther 264:271-5 (1993). Read more (PubMed: 8423530) »

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