Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SequenceCLREQGRGKDQPGRL

Associated products

Specifications

Our Abpromise guarantee covers the use of ab45605 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-58K Golgi protein antibody (ab23932)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • Formimidoyltetrahydrofolate cyclodeaminase
    • Formimidoyltransferase cyclodeaminase
    • Formiminotetrahydrofolate cyclodeaminase
    • Formiminotransferase cyclodeaminase
    • Formiminotransferase-cyclodeaminase
    • FTCD
    • FTCD_HUMAN
    • Glutamate formiminotransferase
    • Glutamate formyltransferase
    • LCHC 1
    • LCHC1
    see all
  • FunctionFolate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.
    Binds and promotes bundling of vimentin filaments originating from the Golgi.
  • PathwayAmino-acid degradation; L-histidine degradation into L-glutamate; L-glutamate from N-formimidoyl-L-glutamate (transferase route): step 1/1.
    One-carbon metabolism; tetrahydrofolate interconversion.
  • Involvement in diseaseDefects in FTCD are the cause of glutamate formiminotransferase deficiency (FIGLU-URIA) [MIM:229100]; also known as formiminoglutamicaciduria (FIGLU-uria). It is an autosomal recessive disorder. Features of a severe phenotype, include elevated levels of formiminoglutamate (FIGLU) in the urine in response to histidine administration, megaloblastic anemia, and mental retardation. Features of a mild phenotype include high urinary excretion of FIGLU in the absence of histidine administration, mild developmental delay, and no hematological abnormalities.
  • Sequence similaritiesIn the C-terminal section; belongs to the cyclodeaminase/cyclohydrolase family.
    In the N-terminal section; belongs to the formiminotransferase family.
  • Cellular localizationCytoplasm > cytoskeleton > centrosome > centriole. Golgi apparatus. More abundantly located around the mother centriole.
  • Information by UniProt

References for 58K Golgi protein peptide (ab45605)

ab45605 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab45605.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"