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Product Name
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5HT1A Receptor antibody
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See all 5HT1A Receptor antibodies (7)...
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Product type
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Primary antibodies
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Description
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Goat polyclonal to 5HT1A Receptor
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Note on antibody grade |
Fast-Track antibodies
- Immunogen affinity purified
- high ELISA titre values
- released early (to accelerate your research)
- 950 Abpoints to the 1st researcher
who submits conclusive data (positive or negative):
Read the Fast-Track antibody Terms of Use
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Immunogen
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Synthetic peptide: KTVKKVEKTGADT, corresponding to Internal sequence amino acids 228-240 of Human 5HT1A Receptor
BLAST 'KTVKKVEKTGADT' with  or 
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Predicted to react
(species key)
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Hu, Ms, Rat, Dog
(Due to sequence homology)
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Specificity
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No crossreactivity expected with other serotonin receptors.
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Abreviews
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Application notes
(see key)
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Recommended dilutions
This antibody gave a positive result in ELISA against the immunizing peptide. Antibody detection limit dilution 1:64,000.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Membrane; multi-pass membrane protein.
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Research areas
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Cancer >> Signal transduction >> G protein signaling >> GPCR
Neuroscience >> Endocrine system >> hypothalamic pituitary adrenal axis
Signal Transduction >> Signaling Pathway >> G Protein Signaling >> GPCR
Neuroscience >> Neurotransmission >> Receptors / Channels >> GPCR >> Serotonin Receptors
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Relevance
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5-HT receptors are receptors for the neurotransmitter and peripheral signal mediator 5-hydroxytryptamine (5-HT), also known as serotonin. 5-HT receptors are of great interest as they also mediate the effects of a broad range of pharmaceutical and hallucinogenic drugs. Like most other members of this family, the 5HT1A receptor (also referred to as 5HT receptor 1A or serotonin receptor 1A) is a G-protein coupled receptor. It acts by decreasing cellular levels of cAMP and causes neuronal inhibition. In mammals, 5HT1A receptor expression is strongest in CNS limbic pathways that control emotion, and 5HT1A receptor function is associated with a number of behavioural effects (sleep, feeding, thermoregulation, aggression and anxiety). Agonists for the 5HT1A receptor include LSD, buspirone, and psilocin.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Goat
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Immunogen affinity purified
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Storage buffer
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Preservative: 0.02% Sodium Azide
Constituents: 0.5% BSA, Tris saline. pH 7.3 Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Purification notes
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Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
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Form
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Liquid
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Concentration
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0.500 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this 5HT1A Receptor antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to 5HT1A Receptor
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5HT1A Receptor antibody - more information
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Customer reviews (feedback) regarding 5HT1A Receptor antibody |
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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