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Product Name
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5HT1A Receptor antibody
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See all 5HT1A Receptor antibodies (7)...
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Product type
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Primary antibodies
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Description
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Guinea pig polyclonal to 5HT1A Receptor
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Immunogen
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Synthetic peptide (PPPKKSLNGQPGSGD) corresponding to amino acids 248-262 of the third intracytoplasmic loop of the mouse and rat 5-HT1A-receptor, conjugated to bovine thyroglobulin.
BLAST 'PPPKKSLNGQPGSGD' with  or 
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Reacts with
(species key)
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Ms, Rat
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Specificity
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ab54469 recognizes the 5HT1A receptor protein
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Tested applications
(see key)
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IHC-Fr
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Abreviews
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Application notes
(see key)
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Recommended dilutions
IHC-Fr: 1/2000.
Suitable for indirect immunofluorescence histochemistry using confocal microscopy and tissue fixed in 4% paraformaldehyde, 0.4% picric acid in 160 mM sodium phosphate buffer, pH 6.9. Use of a Cy3-conjugated donkey anti-guinea pig secondary antibody, (1:250) is recommended.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Positive control
(see definition)
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Mouse or rat tissue sections from central nervous system (CNS)
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Cellular localization
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Membrane; multi-pass membrane protein.
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Research areas
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Cancer >> Signal transduction >> G protein signaling >> GPCR
Neuroscience >> Endocrine system >> hypothalamic pituitary adrenal axis
Signal Transduction >> Signaling Pathway >> G Protein Signaling >> GPCR
Neuroscience >> Neurotransmission >> Receptors / Channels >> GPCR >> Serotonin Receptors
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Relevance
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5-HT receptors are receptors for the neurotransmitter and peripheral signal mediator 5-hydroxytryptamine (5-HT), also known as serotonin. 5-HT receptors are of great interest as they also mediate the effects of a broad range of pharmaceutical and hallucinogenic drugs. Like most other members of this family, the 5HT1A receptor (also referred to as 5HT receptor 1A or serotonin receptor 1A) is a G-protein coupled receptor. It acts by decreasing cellular levels of cAMP and causes neuronal inhibition. In mammals, 5HT1A receptor expression is strongest in CNS limbic pathways that control emotion, and 5HT1A receptor function is associated with a number of behavioural effects (sleep, feeding, thermoregulation, aggression and anxiety). Agonists for the 5HT1A receptor include LSD, buspirone, and psilocin.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Guinea pig
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Whole antiserum
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Storage buffer
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Preservative: None
Constituents: Whole serum
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Form
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Liquid
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Concentration
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Concentration not determined - why is this?
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this 5HT1A Receptor antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to 5HT1A Receptor
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