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Anti-5HT3A Receptor antibody (ab79228)

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Overview

  • Product nameAnti-5HT3A Receptor antibody
  • Description
    Rabbit polyclonal to 5HT3A Receptor
  • Tested applicationsWB, IHC-P, IHC-Fr more details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Rat
  • Immunogen

    Synthetic peptide (Mouse)

Properties

Applications

Our Abpromise guarantee covers the use of ab79228 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB
IHC-P
IHC-Fr
  • Application notesIHC-P: 1/300 - 1/2000. Antigen retrieval is recommended.
    IHC-Fr: 1/300 - 1/2000.
    WB: 1/300 - 1/2000. Predicted molecular weight: 55 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Target

    • RelevanceThe monoamine serotonin (5-hydroxytryptamine) mediates a variety of physiological actions by binding to a number of distinct receptors, pharmacologically classified into several major groups which differ in tissue and cellular localization, affinity for serotonin, and second messenger pathways. The majority of these receptors stimulate a GTP-binding protein upon agonist stimulation and couple to adenylate cyclase or phospholipase C. In contrast, the 5-HT3 receptor is a ligand-gated ion channel that mediates a fast excitatory response. This receptor is a member of the superfamily of ligand-gated ion channels related to the nicotinic, GABAA and NMDA receptors. Although the 5-HT3 receptor was initially identified from the neuroblastoma cell line NCB-20, radioligand binding studies and in situ hybridization studies have localized the 5-HT3 receptor to a unique distribution of neurons, supporting possible roles for the receptor in cognition and sensory input. Recent immunohistochemical analysis of the rat brain revealed a broad distribution of 5-HT3 immunoreactivity, primarily including interneurons and motor neurons. There are two named isoforms.
    • Cellular localizationIntegral to plasma membrane
    • Database links
      • Alternative names
          5 HT3A antibody5 hydroxytryptamine 3 receptor antibody5 Hydroxytryptamine receptor 3 antibody
          5 Hydroxytryptamine receptor 3A antibody5 Hydroxytryptamine Serotonin Receptor 3a antibody5HT3R antibodyHTR3 antibodyHtr3a antibodySerotonin gated ion channel receptor antibody
        see all

      References for Anti-5HT3A Receptor antibody (ab79228)

      ab79228 has not yet been referenced specifically in any publications.

      Publishing research using ab79228 ? Please let us know so that we can cite the reference in this datasheet

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      I have used ab79228 to stain mouse brain sections via IHC-Fr. However there is no staining. I used 1:100 - 1:1000 dilution of the primary and overnight incubation of primary at 4 deg C. Also used ABC staining.

      I am sorry this product did not perform as stated on the datasheet and for the inconvenience this has caused. As requested, I have issued a free of charge replacement for one vial of ab13897. To check the status of the order please contact our Cust...

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      Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"