You have changed your country from  to  . Please be aware that this will change the currency in the purchasing process.

Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab37332 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: Use a concentration of 1 µg/ml. Predicted molecular weight: 55 kDa.

Target

  • FunctionThis is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel.
  • Tissue specificityExpressed in cerebral cortex, amygdala, hippocampus, and testis. Detected in monocytes of the spleen and tonsil, in small and large intestine, uterus, prostate, ovary and placenta.
  • Sequence similaritiesBelongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3A sub-subfamily.
  • Cellular localizationCell junction > synapse > postsynaptic cell membrane. Cell membrane.

    • Target information above from: UniProt accession P46098 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    • Alternative names
        5 HT 3 antibody5 HT3 receptor antibody5 HT3A antibody
        5 HT3A receptor antibody5 HT3R antibody5 HT3RA antibody5 hydroxytryptamine (serotonin) receptor 3A antibody5-HT-3 antibody5-HT3-A antibody5-HT3A antibody5-HT3R antibody5-hydroxytryptamine receptor 3 antibody5-hydroxytryptamine receptor 3A antibody5HT 3 antibody5HT receptor antibody5HT3 serotonin receptor antibody5HT3A_HUMAN antibody5HT3R antibodyHTR3 antibodyHtr3a antibodySerotonin gated ion channel receptor antibodySerotonin receptor 3A antibodySerotonin-gated ion channel receptor 3a antibodySerotonin-gated ion channel receptor antibody
      see all

    References for Anti-5HT3A receptor antibody (ab37332)

    This product has been referenced in:
    • Mastrangelo L  et al. Serotonin receptors, novel targets of sulforaphane identified by proteomic analysis in Caco-2 cells. Cancer Res 68:5487-91 (2008). WB ; Human . Read more (PubMed: 18593952) »

    See 1 Publication for this product

    Publishing research using ab37332 ? Please let us know so that we can cite the reference in this datasheet

    Product Wall

    Submit an Abreview for ab37332 Submit a Question for ab37332

    Displaying 1 - 2 of 2 results for Abreviews and Q&A

    10
    Votes: Highest First

    Hi Abcam,



    A customer is interested in testing a 5HT3A in flowcyt. As there are 8 available, are there any that may be more likely to work in flow cyt than others?



    Thank you for your prompt reply to my query re...

    Read More

    Thank you very much for your inquiry.

    If I understand your customers plans correctly, they are looking for an antibody that can block the binding site of the receptor which would be a functional application.

    According the the Swiss Pro...

    Read More

    A customer wants to use this ab for WB on rat samples instead on human. The immunogen sequence is not specified so that we can not compare the sequence and check homology to rat. Could you please send us this information? It is urgent, since they want to ...

    Read More

    Thank you for contacting Abcam. This product recognizes an epitope on the N-terminal region of human 5HT3A receptor. I apologize that I cannot give you the exact amino acid residues as this information is commercially sensitive. Based on homolo...

    Read More

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"