Anti-5HT1B Receptor antibody (ab13896)
Key features and details
- Rabbit polyclonal to 5HT1B Receptor
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Overview
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Product name
Anti-5HT1B Receptor antibody
See all 5HT1B Receptor primary antibodies -
Description
Rabbit polyclonal to 5HT1B Receptor -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details
Unsuitable for: IHC-Fr or IHC-P -
Species reactivity
Reacts with: Mouse, Rat, Human -
Immunogen
Synthetic peptide corresponding to Rat 5HT1B Receptor. 8-26(CAPPPPATSQTGVPLANLS) and 263-278(VTSINSRVPEVPSESG)
Database link: P28564 -
Positive control
- WB: Human brain lysate.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.40
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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Purity
Protein G purified -
Purification notes
This antibody is affinity purified. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab13896 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
Use a concentration of 1 µg/ml. Detects a band of approximately 40-41 kDa (predicted molecular weight: 47 kDa).
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Notes |
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WB
Use a concentration of 1 µg/ml. Detects a band of approximately 40-41 kDa (predicted molecular weight: 47 kDa). |
Target
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Function
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. -
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. -
Post-translational
modificationsPhosphorylated. Desensitization of the receptor may be mediated by its phosphorylation.
Palmitoylated. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 3351 Human
- Entrez Gene: 15551 Mouse
- Entrez Gene: 25075 Rat
- Omim: 182131 Human
- SwissProt: P28222 Human
- SwissProt: P28334 Mouse
- SwissProt: P28564 Rat
- Unigene: 123016 Human
see all -
Alternative names
- 5 HT1DB antibody
- 5 hydroxytryptamine receptor 1B antibody
- 5-HT-1B antibody
see all
Images
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (19)
ab13896 has been referenced in 19 publications.
- Edvinsson JCA et al. Lasmiditan and 5-Hydroxytryptamine in the rat trigeminal system; expression, release and interactions with 5-HT1 receptors. J Headache Pain 23:26 (2022). PubMed: 35177004
- Song JH et al. Improvement Effects of Myelophil on Symptoms of Chronic Fatigue Syndrome in a Reserpine-Induced Mouse Model. Int J Mol Sci 22:N/A (2021). PubMed: 34638540
- Pu ZH et al. Alkaloids from the rhizomes of Ligusticum striatum exert antimigraine effects through regulating 5-HT1B receptor and c-Jun. J Ethnopharmacol 237:39-46 (2019). PubMed: 30880256
- Frederiksen SD et al. Expression of Pituitary Adenylate Cyclase-activating Peptide, Calcitonin Gene-related Peptide and Headache Targets in the Trigeminal Ganglia of Rats and Humans. Neuroscience 393:319-332 (2018). PubMed: 30336190
- Han X et al. Electroacupuncture restores hippocampal synaptic plasticity via modulation of 5-HT receptors in a rat model of depression. Brain Res Bull 139:256-262 (2018). WB . PubMed: 29524471