Tissue specificityExpressed by all types of trophoblasts as early as 9 weeks of development. Specific for trophoblastic cells except for amniotic epithelium. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma.
Form5T4 is a 72 kDa transmembrane glycoprotein that exhibits restricted expression in human and mouse adult tissues, is upregulated on many carcinomas and tumour expression correlates with poorer clinical outcome in ovarian, gastric and colorectal cancers. mES cells lack cell surface expression of the 5T4 antigen, and both protein and mRNA are rapidly upregulated following induction of differentiation. This proteins expression correlates with downregulation of OCT-4 and Tra-1–60 (Ward et al., 2006).
5T4 oncofetal antigen antibody
5T4 oncofetal trophoblast glycoprotein antibody
5T4 oncotrophoblast glycoprotein antibody
Trophoblast glycoprotein antibody
Anti-5T4 antibody images
Western blot - Anti-5T4 antibody (ab130522)
Anti-5T4 antibody (ab130522) at 1/100 dilution + A2058 cell line lysate at 35 µg
Predicted band size : 46 kDa
References for Anti-5T4 antibody (ab130522)
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