Overview

  • Product nameAnti-5T4 antibody
    See all 5T4 primary antibodies
  • Description
    Rabbit polyclonal to 5T4
  • Tested applicationsWBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 168-197 of Human 5T4 (NP_001159864.1, NP_006661.1).

  • Positive control
    • A2058 cell line lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab130522 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 46 kDa.

Target

  • Tissue specificityExpressed by all types of trophoblasts as early as 9 weeks of development. Specific for trophoblastic cells except for amniotic epithelium. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma.
  • Sequence similaritiesContains 6 LRR (leucine-rich) repeats.
    Contains 1 LRRCT domain.
    Contains 1 LRRNT domain.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Form5T4 is a 72 kDa transmembrane glycoprotein that exhibits restricted expression in human and mouse adult tissues, is upregulated on many carcinomas and tumour expression correlates with poorer clinical outcome in ovarian, gastric and colorectal cancers. mES cells lack cell surface expression of the 5T4 antigen, and both protein and mRNA are rapidly upregulated following induction of differentiation. This proteins expression correlates with downregulation of OCT-4 and Tra-1–60 (Ward et al., 2006).
  • Alternative names
    • 5T4 antibody
    • 5T4 oncofetal antigen antibody
    • 5T4 oncofetal trophoblast glycoprotein antibody
    • 5T4 oncotrophoblast glycoprotein antibody
    • 5T4AG antibody
    • AW495680 antibody
    • M6P1 antibody
    • TPBG antibody
    • TPBG_HUMAN antibody
    • Trophoblast glycoprotein antibody
    see all

Anti-5T4 antibody images

  • Anti-5T4 antibody (ab130522) at 1/100 dilution + A2058 cell line lysate at 35 µg

    Predicted band size : 46 kDa

References for Anti-5T4 antibody (ab130522)

ab130522 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab130522.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"