Anti-5T4 antibody (ab130522)
- Product nameAnti-5T4 antibodySee all 5T4 primary antibodies ...
- DescriptionRabbit polyclonal to 5T4
- Tested applicationsWB more details
- Species reactivityReacts with: Human
Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 168-197 of Human 5T4 (NP_001159864.1, NP_006661.1).
- Positive control
- A2058 cell line lysate
- Storage instructionsStore at 4°C (up to 6 months). For long term storage store at -20°C
- Storage bufferPreservative: 0.09% Sodium azide
Constituent: 99% PBS
- Concentration information loading...
- PurityImmunogen affinity purified
- Purification notesab130522 is purified through a protein A column, followed by peptide affinity purification.
- Clonality Polyclonal
Our Abpromise guarantee covers the use of ab130522 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||WB: 1/100 - 1/500. Predicted molecular weight: 46 kDa.|
- Tissue specificityExpressed by all types of trophoblasts as early as 9 weeks of development. Specific for trophoblastic cells except for amniotic epithelium. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma.
- Sequence similaritiesContains 6 LRR (leucine-rich) repeats.
Contains 1 LRRCT domain.
Contains 1 LRRNT domain.
- Cellular localizationMembrane.
- Form5T4 is a 72 kDa transmembrane glycoprotein that exhibits restricted expression in human and mouse adult tissues, is upregulated on many carcinomas and tumour expression correlates with poorer clinical outcome in ovarian, gastric and colorectal cancers. mES cells lack cell surface expression of the 5T4 antigen, and both protein and mRNA are rapidly upregulated following induction of differentiation. This proteins expression correlates with downregulation of OCT-4 and Tra-1–60 (Ward et al., 2006).
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Anti-5T4 antibody images
Anti-5T4 antibody (ab130522) at 1/100 dilution + A2058 cell line lysate at 35 µg
Predicted band size : 46 kDa
References for Anti-5T4 antibody (ab130522)
ab130522 has not yet been referenced specifically in any publications.