67kDa Laminin Receptor antibody [SPM278] (ab52977)

Product Name 

67kDa Laminin Receptor antibody [SPM278]

Product type 

Primary antibodies

Description 

Mouse monoclonal [SPM278] to 67kDa Laminin Receptor

Immunogen 

Small cell lung carcinoma N592 live cells

Reacts with 
(species key)

Hu

Tested applications 
(see key)

Flow Cyt, ICC/IF, IHC-P

Abreviews 

Customer reviews (see key)

Read about Abreviews

Application notes 
(see key)

Recommended dilutions
Flow Cyt: Use at an assay dependent dilution.
ICC/IF: 1/25.
IHC-P: 1/25. Antigen retrieval requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Positive control 
(see definition)

Human breast carcinoma

Cellular localization 

Cell Membrane and Cytoplasmic

Research areas 

Neuroscience >> Cell Adhesion Proteins >> ECM Proteins
Signal Transduction >> Cytoskeleton / ECM >> Basal Lamina
Neuroscience >> Cell Adhesion Proteins >> Cytoskeletal Proteins >> Intermediate Filaments
Neuroscience >> Neurology process >> Neurodegenerative disease >> Prions
Cardiovascular >> Angiogenesis >> Adhesion / ECM >> Extracellular Matrix

Relevance 

Laminin, one of the major glycoproteins of basement membrane, displays multiple biological activities which are mediated through its interaction with specific cell membrane receptors. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein.
Overexpression of Laminin Receptor is reportedly an independent prognostic factor in breast cancer and correlates with the dissemination of the tumor cells in bone marrow. Laminin Receptors appears to play an important role in tumor invasion and metastasis.

Database links 

Raised in 

Mouse

Clonality 

Monoclonal

Clone number 

SPM278

Isotype 

IgM

Purity 

Ammonium Sulphate Precipitation

Storage buffer 

Preservative: 0.05% Sodium Azide
Constituents: 0.2% BSA, PBS, pH 7.4

Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS

Purification notes 

ab52977 was purified from ascitic fluid.

Form 

Liquid

Concentration 

0.200 mg/ml

Storage instructions 

Store at +4°C.

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