Overview

  • Product name
    7,7-Dimethyleicosadienoic acid
  • Description
    PLA2 inhibitor. Arachadonic acid analog.
  • Biological description
    Phopholipase A2 inhibitor (IC50 = 16 μM). Inhibits COX and lipoxygenase pathways (IC50 values are 56 and 14 μM respectively). Inhibits production of PGE2 (IC50 = 2 μM). Arachadonic acid analog (ab120916). Cell permeable.
  • Purity
    > 99%

Properties

    References for 7,7-Dimethyleicosadienoic acid (ab141544)

    This product has been referenced in:
    • Björnsdottir H  et al. Inhibition of phospholipase A(2) abrogates intracellular processing of NADPH-oxidase derived reactive oxygen species in human neutrophils. Exp Cell Res 319:761-74 (2013). Read more (PubMed: 23274527) »
    • Harish OE & Poo MM Retrograde modulation at developing neuromuscular synapses: involvement of G protein and arachidonic acid cascade. Neuron 9:1201-9 (1992). Read more (PubMed: 1334421) »
    • Sargent CA  et al. Effect of the phospholipase A2 inhibitors quinacrine and 7,7-dimethyleicosadienoic acid in isolated globally ischemic rat hearts. J Pharmacol Exp Ther 262:1161-7 (1992). Read more (PubMed: 1382129) »
    • Lister MD  et al. Inhibition studies on the membrane-associated phospholipase A2 in vitro and prostaglandin E2 production in vivo of the macrophage-like P388D1 cell. Effects of manoalide, 7,7-dimethyl-5,8-eicosadienoic acid, and p-bromophenacyl bromide. J Biol Chem 264:8520-8 (1989). Read more (PubMed: 2498315) »

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