Phopholipase A2 inhibitor (IC50 = 16 μM). Inhibits COX and lipoxygenase pathways (IC50 values are 56 and 14 μM respectively). Inhibits production of PGE2 (IC50 = 2 μM). Arachadonic acid analog (ab120916). Cell permeable.
Store at +4°C. The product can be stored for up to 12 months.
Soluble in ethanol
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
References for 7,7-Dimethyleicosadienoic acid (ab141544)
This product has been referenced in:
Björnsdottir H et al. Inhibition of phospholipase A(2) abrogates intracellular processing of NADPH-oxidase derived reactive oxygen species in human neutrophils. Exp Cell Res319:761-74 (2013).
Read more (PubMed: 23274527) »
Harish OE & Poo MM Retrograde modulation at developing neuromuscular synapses: involvement of G protein and arachidonic acid cascade. Neuron9:1201-9 (1992).
Read more (PubMed: 1334421) »
Sargent CA et al. Effect of the phospholipase A2 inhibitors quinacrine and 7,7-dimethyleicosadienoic acid in isolated globally ischemic rat hearts. J Pharmacol Exp Ther262:1161-7 (1992).
Read more (PubMed: 1382129) »
Lister MD et al. Inhibition studies on the membrane-associated phospholipase A2 in vitro and prostaglandin E2 production in vivo of the macrophage-like P388D1 cell. Effects of manoalide, 7,7-dimethyl-5,8-eicosadienoic acid, and p-bromophenacyl bromide. J Biol Chem264:8520-8 (1989).
Read more (PubMed: 2498315) »