7,8-Dihydroxyflavone (7,8-DHF) (ab120996)

Overview

  • Product name
    7,8-Dihydroxyflavone (7,8-DHF)
  • Description
    Selective TrkB receptor agonist. Flavonoid.
  • Biological description
    Selective TrkB receptor agonist. Flavonoid. Enhances synaptic plasticity in vivo and in vitro. Blood-brain barrier permeable.
  • Purity
    > 99%

Properties

References

This product has been referenced in:
  • Devi L & Ohno M 7,8-dihydroxyflavone, a small-molecule TrkB agonist, reverses memory deficits and BACE1 elevation in a mouse model of Alzheimer's disease. Neuropsychopharmacology 37:434-44 (2012). Read more (PubMed: 21900882) »
  • Zeng Y  et al. 7,8-dihydroxyflavone rescues spatial memory and synaptic plasticity in cognitively impaired aged rats. J Neurochem 122:800-11 (2012). Read more (PubMed: 22694088) »
  • Jang SW  et al. A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone. Proc Natl Acad Sci U S A 107:2687-92 (2010). Read more (PubMed: 20133810) »

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Customer reviews and Q&As

Some products may be difficult to solubilise it may be that rapid stirring, warming in a water bath, or sonication of the solution may help.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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