Overview

  • Product name
    7α-Hydroxycholesterol
  • Description
    Bile acid precursor. Displays pro-inflammatory activity.
  • Alternative names
    • 7 alpha-hydroxycholesterol
    • 7alpha-hydroxycholesterol
  • Biological description

    Bile acid precursor produced by cholesterol 7 alpha-hydroxylase. Induces inflammation by enhancing production of chemokine (C-C motif) ligand 2. Elicits TLR6-Mediated Expression of IL-23 in Monocytic Cells.

Properties

  • Molecular weight
    402.65
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C27H46O2
  • CAS Number
    566-26-7
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CC(C)CCC[C@@H](C)[C@H]4CC[C@@H]3[C@]4(C)CC[C@H]2[C@H]3C(O)C=C1C[C@@H](O)CC[C@@]12C
  • Source

    Synthetic

References

This product has been referenced in:
  • Kim SM  et al. 7a-Hydroxycholesterol induces inflammation by enhancing production of chemokine (C-C motif) ligand 2. Biochem Biophys Res Commun 467:879-84 (2015). Read more (PubMed: 26474699) »
  • Seo HC  et al. 7a-Hydroxycholesterol Elicits TLR6-Mediated Expression of IL-23 in Monocytic Cells. Biomol Ther (Seoul) 23:84-9 (2015). Read more (PubMed: 25593648) »
  • Hahn C  et al. Serum concentration of 7 alpha-hydroxycholesterol as an indicator of bile acid synthesis in humans. J Lipid Res 36:2059-66 (1995). Read more (PubMed: 8558093) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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