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Product name
8-(3-Chlorostyryl)caffeine
Description
Selective A2A receptor antagonist. MAO-B inhibitor.
Biological description
Selective A2A receptor antagonist and MAO-B (monoamine oxidase B) inhibitor (Ki values are 54 and 100 nM respectively). Affords strong neuroprotection against 6-OHDA-induced neurotoxicity in vitro and is neuroprotective in Parkinson’s disease models.
Purity
> 98%
General notes
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Properties
Chemical name
(E)-8-[2-(3-Chlorophenyl)ethenyl]-3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
Molecular Weight
330.77
Chemical structure
Molecular formula
C16H15ClN4O2
CAS Number
147700-11-6
Solubility
Soluble in DMSO to 25 mM (with heating)
Storage instructions
Store at -20°C (desiccating conditions).
Research areas
Biochemicals >> Research Area >> Stroke >> Adenosine >> A2
Biochemicals >> Research Area >> Respiratory disease >> Adenosine >> A2
Biochemicals >> Research Area >> Heart disease >> Adenosine >> A2
Biochemicals >> Pharmacology >> Enzymes >> Oxidases >> MAO >> Inhibitors
Biochemicals >> Pharmacology >> Receptors & Transporters >> Purinergics >> P1 >> Antagonists
Biochemicals >> Pharmacology >> Receptors & Transporters >> Adenosine >> A2 >> Antagonists
Biochemicals >> Pharmacology >> Receptors & Transporters >> Adenosine >> A2
Biochemicals >> Chemical Type >> Biochemicals
References for 8-(3-Chlorostyryl)caffeine (ab120442)
This product has been referenced in:
- Nobre HV et al. Caffeine and CSC, adenosine A2A antagonists, offer neuroprotection against 6-OHDA-induced neurotoxicity in rat mesencephalic cells. Neurochem Int 56:51-8 (2010).Read more (PubMed: 19782116) »
- Chen JF et al. 8-(3-Chlorostyryl)caffeine may attenuate MPTP neurotoxicity through dual actions of monoamine oxidase inhibition and A2A receptor antagonism. J Biol Chem 277:36040-4 (2002).Read more (PubMed: 12130655) »
See all 3 publications for this product
Publishing research using ab120442? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"