Overview

  • Product name8-(3-Chlorostyryl)caffeine
  • Description
    Selective A2A receptor antagonist. MAO-B inhibitor.
  • Biological descriptionSelective A2A receptor antagonist and MAO-B (monoamine oxidase B) inhibitor (Ki values are 54 and 100 nM, respectively). Affords strong neuroprotection against 6-OHDA-induced neurotoxicity in vitro and is neuroprotective in Parkinson's disease models.
  • Purity> 98%

Properties

    References for 8-(3-Chlorostyryl)caffeine (ab120442)

    This product has been referenced in:
    • Nobre HV  et al. Caffeine and CSC, adenosine A2A antagonists, offer neuroprotection against 6-OHDA-induced neurotoxicity in rat mesencephalic cells. Neurochem Int 56:51-8 (2010). Read more (PubMed: 19782116) »
    • Chen JF  et al. 8-(3-Chlorostyryl)caffeine may attenuate MPTP neurotoxicity through dual actions of monoamine oxidase inhibition and A2A receptor antagonism. J Biol Chem 277:36040-4 (2002). Read more (PubMed: 12130655) »
    • Jacobson KA  et al. 8-(3-Chlorostyryl)caffeine (CSC) is a selective A2-adenosine antagonist in vitro and in vivo. FEBS Lett 323:141-4 (1993). Read more (PubMed: 8495727) »

    See 0 Publications for this product

    Product Wall

    There are currently no Abreviews or Questions for ab120442.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"