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Anti-8 Hydroxyguanosine antibody (ab93701)

Submit an Abreview Q&A (3)

Overview

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: Whole serum
  • PurityWhole antiserum
  • Clonality Polyclonal
  • IsotypeIgG
  • Research Areas

Applications

Our Abpromise guarantee covers the use of ab93701 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
IHC-P
  • Application notesIHC-P: 1/200.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Target

    • Relevance8-Hydroxydeoxyguanosine (8OHdG) is a modified base that occurs in DNA due to attack by hydroxyl radicals that are formed as byproducts and intermediates of aerobic metabolism and during oxidative stress. There is increasing evidence to support the involvement of free radical reactions in the damage of biomolecules that eventually lead to several diseases in humans, such as atherosclerosis, cerebral and heart ischemia-reperfusion injury, cancer, rheumatoid arthritis, inflammation, diabetes, aging, and neurodegenerative conditions, such as Alzheimer’s disease. 8OHdG has become increasing popular as a sensitive, stable and integral marker of oxidative damage in cellular DNA. Biomonitoring in humans has demonstrated that 8OHdG can be excreted in the urine, and that a significant increase is caused by exposure to tobacco smoke and ionizing radiation. Because 8OHdG is so well correlated with oxidative stress and damage to DNA, which leads to degenerative disease states, the development of an antibody that can be used to study DNA damage has numerous applications. In addition to the direct study of DNA damage within cells, this antibody has applications in the development of immunoassays that can monitor 8OHdG excretion in the urine and serve as a biomarker of oxidative stress.
    • Alternative names
        8 hydroxy 2’ deoxyguanosine antibody8 hydroxyguanine antibody8 hydroxyguanosine antibody
        8 OHG antibody8-OHG antibody8OG antibody8OHdG antibody8OHG antibody
      see all

    Anti-8 Hydroxyguanosine antibody images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - 8 Hydroxyguanosine antibody (ab93701)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - 8 Hydroxyguanosine antibody (ab93701)
      ab93701, at a 1/200 dilution, staining 8 Hydroxyguanosine in oxidized RNA in neurons from formalin fixed, paraffin embedded Alzheimer's brain tissue by Immunohistochemistry. The tissue was pretreated with 10 µg/ml proteinase K for 40 minutes at 37 °C.

    References for Anti-8 Hydroxyguanosine antibody (ab93701)

    ab93701 has not yet been referenced specifically in any publications.

    Publishing research using ab93701 ? Please let us know so that we can cite the reference in this datasheet

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    Phoned to ask if product had been tested in analogues. Also wondering ifAnti-8 Hydroxyguanosine antibodywould recognize8-Hydroxy-2'-deoxyguanosine antibody.

    I have now heard back about all of the antibodies and for ab93701 we have not tested the Ab to determine if it recognizes 8-Hydroxy-2'-deoxyguanosine.
    If there is anything else i can help you with, please let me know.

    I am writing to see if you have heard back about the cross reactivity of the following antibodies:ab48508, ab93701. Please see the email below for a refresher regarding our original exchange which took place a month ago. Thank you for your time.

    Thank you for your reply.
    I have still not heard back from all of those products. I am going to send email reminders and follw up with what is happening. I will get back to you as soon as I find out anything.
    Thank you for your patience.

    Phoned to ask if product had been tested in analogues. Also wondering if Anti-8 Hydroxyguanosine antibody would recognize 8-Hydroxy-2'-deoxyguanosine antibody.

    Thank you for contacting us.

    I have been in contact with the labs about the products that you had called about. Not all of my requests have been returned yet, however I have received some information and wanted to pass that on to you.

    a...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"