Overview

  • Product name
    8-Azaguanine
  • Description
    Purine analogue with potential antineoplastic activity. Competes with guanine in metabolism.
  • Alternative names
    • 2-Amino-6-hydroxy-8-azapurine
    • 2-Amino-6-oxy-8-azapurine
    • 7H-1,2,3-Triazolo[4,5-d]pyrimidin-7-one, 5-amino-3,6-dihydro-
    • 8-AzaG
    • Guanazolo
    • NSC-749
    • Pathocidine
    • SF-337
    • SK 1150
    see all
  • Biological description

    Purine analogue with potential antineoplastic activity. Antimetabolite. Competes with guanine. Incorporated into ribonucleic acids, interfering with normal biosynthetic pathways, thus inhibiting cellular growth. Has been used in the treatment of acute leukemia.

  • Purity
    > 99%

Properties

  • Chemical name
    5-Amino-3,6-dihydro-7H-1,2,3-triazolo[4,5-d]pyrimidin-7-one
  • Molecular weight
    152.11
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C4H4N6O
  • CAS Number
    134-58-7
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:
  • Dourado M  et al. CD26/DPPIV expression and 8-azaguanine response in T-acute lymphoblastic leukaemia cell lines in culture. Pathophysiology 14:3-10 (2007). Read more (PubMed: 17055708) »
  • Kontsekova E  et al. One-step method for establishing 8-azaguanine-resistant hybridomas suitable for the preparation of triomas. J Immunol Methods 145:247-50 (1991). Read more (PubMed: 1765658) »
  • Berman JJ  et al. Toxicity of 6-thioguanine and 8-azaguanine to non-dividing liver cell cultures. Cell Biol Toxicol 1:67-73 (1985). Read more (PubMed: 3917127) »
  • Rivest RS  et al. Inhibition of initiation of translation in L1210 cells by 8-azaguanine. Biochem Pharmacol 31:2505-11 (1982). Read more (PubMed: 7126262) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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