Standard selective 5-HT1a receptor agonist; affinity for 5-HT7 receptors
Biological descriptionStandard selective 5-HT1a receptor agonist. Moderate affinity for 5-HT7 receptors (pKi = 6.6) and able to antagonise 5-HT reuptake. Variety of biological effects seen in vivo.
Chemical name(±)-8-Hydroxy-2-dipropylaminotetralin hydrobromide
Storage instructionsStore at +4°C. Store under Desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 10 mM and in ethanol to 5 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
References for 8-Hydroxy-DPAT hydrobromide (ab120582)
This product has been referenced in:
Yelleswarapu NK et al. Elucidating the role of 5-HT(1A) and 5-HT(7) receptors on 8-OH-DPAT-induced behavioral recovery after experimental traumatic brain injury. Neurosci Lett515:153-6 (2012).
Read more (PubMed: 22465320) »
Wood M et al. Antagonist activity of meta-chlorophenylpiperazine and partial agonist activity of 8-OH-DPAT at the 5-HT(7) receptor. Eur J Pharmacol396:1-8 (2000).
Read more (PubMed: 10822046) »
Assié MB & Koek W Possible in vivo 5-HT reuptake blocking properties of 8-OH-DPAT assessed by measuring hippocampal extracellular 5-HT using microdialysis in rats. Br J Pharmacol119:845-50 (1996).
Read more (PubMed: 8922730) »
Gerber R et al. Rotational behavior induced by 8-hydroxy-DPAT, a putative 5HT-1A agonist, in 6-hydroxydopamine-lesioned rats. Psychopharmacology (Berl)94:178-82 (1988).
Read more (PubMed: 2965396) »