Anti-8 Hydroxyguanosine antibody [3H30] (ab17647)

Overview

  • Product nameAnti-8 Hydroxyguanosine antibody [3H30]
    See all 8 Hydroxyguanosine primary antibodies
  • Description
    Mouse monoclonal [3H30] to 8 Hydroxyguanosine
  • SpecificityRecognizes 8 Hydroxy-2'dexoyguanosine, 8 Hydroxyguanine and 8 Hydroxyguanosine from all species.
  • Tested applicationsSuitable for: ELISAmore details
  • Species reactivity
    Reacts with a wide range of species.
  • Immunogen

    8 Hydroxyguanosine, BSA and casein coupled.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferpH: 7.40
    Preservative: 0.09% Sodium azide
    Constituent: PBS
  • Concentration information loading...
  • PurityProtein A purified
  • ClonalityMonoclonal
  • Clone number3H30
  • IsotypeIgG2a
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab17647 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use a concentration of 0.1 - 5 µg/ml.

Target

  • Relevance8-Hydroxydeoxyguanosine (8OHdG) is a modified base that occurs in DNA due to attack by hydroxyl radicals that are formed as byproducts and intermediates of aerobic metabolism and during oxidative stress. There is increasing evidence to support the involvement of free radical reactions in the damage of biomolecules that eventually lead to several diseases in humans, such as atherosclerosis, cerebral and heart ischemia-reperfusion injury, cancer, rheumatoid arthritis, inflammation, diabetes, aging, and neurodegenerative conditions, such as Alzheimer’s disease. 8OHdG has become increasing popular as a sensitive, stable and integral marker of oxidative damage in cellular DNA. Biomonitoring in humans has demonstrated that 8OHdG can be excreted in the urine, and that a significant increase is caused by exposure to tobacco smoke and ionizing radiation. Because 8OHdG is so well correlated with oxidative stress and damage to DNA, which leads to degenerative disease states, the development of an antibody that can be used to study DNA damage has numerous applications. In addition to the direct study of DNA damage within cells, this antibody has applications in the development of immunoassays that can monitor 8OHdG excretion in the urine and serve as a biomarker of oxidative stress.
  • Alternative names
    • 8 hydroxy 2’ deoxyguanosine antibody
    • 8 hydroxyguanine antibody
    • 8 hydroxyguanosine antibody
    • 8 OHG antibody
    • 8-OHG antibody
    • 8OG antibody
    • 8OHdG antibody
    • 8OHG antibody
    see all

References for Anti-8 Hydroxyguanosine antibody [3H30] (ab17647)

ab17647 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your enquiry regarding ab17647 (Anti-8 Hydroxyguanosine antibody [3H30]) and your patience. The concentration of this antibody is ~6.7 nmoles/ml. 1mg/ml / (150,000g/mole IgG) x 10e-3g/mg = 6.7 x 10e-9 moles/ml. I can confi...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"