A 438079, competitive P2X7 receptor antagonist (ab120413)
Key features and details
- Potent, competitive P2X7 receptor antagonist
- CAS Number: 899431-18-6
- Purity: > 98%
- Soluble in DMSO to 100 mM and in water to 5 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
A 438079, competitive P2X7 receptor antagonist -
Description
Potent, competitive P2X7 receptor antagonist -
Biological description
Potent, competitive P2X7 receptor antagonist (pIC50 = 6.5 nM). Shown to reduce pathological nociception.
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Purity
> 98% -
CAS Number
899431-18-6 -
Chemical structure
Properties
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Chemical name
3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine hydrochloride -
Molecular weight
342.61 -
Molecular formula
C13H9Cl2N5.HCl -
PubChem identifier
11688742 -
Storage instructions
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in water to 5 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.Clc3cccc(c2nnnn2Cc1cnccc1)c3Cl -
Source
Synthetic
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Research areas
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (4)
ab120413 has been referenced in 4 publications.
- Ma Y et al. Potential mechanisms of osteoprotegerin-induced damage to osteoclast adhesion structures via P2X7R-mediated MAPK signaling. Int J Mol Med 49:N/A (2022). PubMed: 35266010
- Wanhainen KM et al. P2RX7 Enhances Tumor Control by CD8+ T Cells in Adoptive Cell Therapy. Cancer Immunol Res 10:871-884 (2022). PubMed: 35588154
- Jiang M et al. P2X7R orchestrates the progression of murine hepatic fibrosis by making a feedback loop from macrophage to hepatic stellate cells. Toxicol Lett 333:22-32 (2020). PubMed: 32721574
- Layhadi JA & Fountain SJ P2X4 Receptor-Dependent Ca2+ Influx in Model Human Monocytes and Macrophages. Int J Mol Sci 18:N/A (2017). PubMed: 29077063