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A 769662

Product code: ab120335 (formerly Asc-335)

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Overview

Product name

A 769662

Description

AMP-activated protein kinase activator

Biological description

Potent, reversible activator of AMP-activated protein kinase (AMPK) (EC50 = 0.8 μM). Directly activates native rat AMPK by mimicking the effects of AMP - it activates AMPK both allosterically and by inhibiting dephosphorylation of AMPK. Shown to inhibit Na+-K+-ATPase at higher concentrations (IC50 = 57 μM) . Inhibits differentiation of adipocytes.

Purity

> 99%

General notes

Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Not currently for sale in the US

Properties

Chemical name

6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile

Molecular Weight

360.39

Chemical structure

Chemical Structure

Molecular formula

C20H12N2O3S

CAS Number

844499-71-4

Solubility

Soluble in DMSO to 100 mM and in ethanol to 25 mM

Storage instructions

Store at +4°C.

Research areas

Biochemicals >> Pharmacology >> Enzymes >> Kinase >> AMP-kinase >> Activators
Biochemicals >> Chemical Type >> Biochemicals

References for A 769662 (ab120335)

This product has been referenced in:

See all 5 publications for this product

Publishing research using ab120335? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"