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AbcamBiochemicals (Asc-287)

A23187 (Calcimycin) (ab120287)

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Overview

  • Product nameA23187 (Calcimycin)
  • Description
    Ca2+ ionophore
  • Alternative names
    calcimycin
  • Biological descriptionA mobile ion-carrier that forms stable complexes with divalent cations. Useful for increasing intracellular Ca2+ levels. Also acts as an uncoupler of oxidative phosphorylation and inhibitor of mitochondrial ATPase activity. An antibiotic with weak activity against Gram-positive bacteria.
  • Purity> 99%

    • Properties

  • Chemical name5-(Methylamino)-2-[[2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)-ethyl]-1,7- dioxaspiro[5.5]undec-2-yl]methyl]-4-benzoxazolecarboxylic acid
  • Molecular Weight523.63
  • Chemical structureChemical Structure
  • Molecular formulaC29H37N3O6
  • CAS Number52665-69-7
  • PubChem identifier11957499
  • Storage instructionsStore at room temperature (desiccating conditions).
  • Solubility overviewSoluble in DMSO to 100 mM (with heating)
  • Handling

    Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

  • SMILESO=C(O)c1c(NC)ccc2oc(nc12)C[C@H]3O[C@@]4(CC[C@H]3C)O[C@@H]([C@H](C)C[C@H]4C)[C@H](C)C(=O)c5cccn5
  • Source

    Steptomyces chartreusensis

  • Research Areas

    • References for A23187 (Calcimycin) (ab120287)

    This product has been referenced in:
    • Boot JH & Van Hilten JA The use of the divalent calcium-ionophore A23187 as a biochemical tool in pharmacological and in vitro toxicological studies. Cell Struct Funct 21:97-9 (1996). Read more (PubMed: 8790938) »
    • Pressman BC Biological applications of ionophores. Annu Rev Biochem 45:501-30 (1976). Read more (PubMed: 786156) »
    • Pfeiffer DR  et al. Ultraviolet and fluorescent spectral properties of the divalent cation ionophore A23187 and its metal ion complexes. Biochemistry 13:4007-14 (1974). Read more (PubMed: 4416784) »

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"